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NCT Number: NCT07616180

Fixed-Mass Different Volumes Bupivacaine TAP Block After Cesarean

Cesarean section is commonly associated with moderate to severe postoperative pain, which may delay mobilisation, impair breastfeeding, and affect mother-infant bonding. Although opioids, NSAIDs, and neuraxial techniques are commonly used for post-cesarean analgesia, their side effects have encouraged the use of peripheral nerve blocks such as the transversus abdominis plane block.

The TAP block is a fascial plane block that provides analgesia by depositing local anaesthetic between the internal oblique and transversus abdominis muscles. Its efficacy after cesarean section has been demonstrated, particularly when long-acting intrathecal opioids are not used. However, the optimal local anaesthetic volume and dose remain unclear. Since the TAP block depends on adequate spread of local anaesthetic, larger volumes may improve analgesic coverage, but increasing the dose may raise the risk of systemic toxicity.

Therefore, this study investigates whether using the same fixed mass of bupivacaine in two different volumes affects the analgesic efficacy of TAP block after cesarean section, hypothesising that the larger volume may provide better postoperative analgesia.

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Key information

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • full-term parturients,
  • aged > 18 years
  • ASA physical status II
  • patients who are scheduled for elective CS with Pfannenstiel incisions under spinal anaesthesia.

Exclusion criteria

  • Parturients with contraindications to spinal anaesthesia,
  • Having a scar or infection at the site of the block
  • BMI > 35 Kg/m2,
  • on chronic use of pain medications,
  • Refusing to participate.

Treatment and study plan

Bupivacaine

Drug

Ultrasound-guided bilateral transversus abdominis plane block using 150 mg plain bupivacaine after cesarean section. The same total bupivacaine dose will be administered in two different volumes: 60 mL total volume, 30 mL per side

Primary outcomes

  1. total postoperative morphine consumption

    Time frame: first 24 hours postoperatively

Study contacts

Contact information is provided by the study sponsor or research team.

Abeer Ahmed, MD

CONTACT

[email protected]

+201005244590

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Ultrasound-guided Transversus Abdominis Plane Block After Cesarean Section Using Two Different Bupivacaine Volumes With a Fixed Drug Mass. A Randomized Comparative Trial.

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jun 1, 2026
Registry last updated
Jun 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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