Hand Rehabilitation Lab
Raleigh, North Carolina, 27695, United States
Location status: Recruiting
Location contact
Derek Kamper, PhD
CONTACT
Mohammad Ghassemi, PhD
CONTACT
NCT Number: NCT05621980
Human development as a species has been strongly associated with the ability to dexterously manipulate objects and tools. Unfortunately, current therapy efforts typically fail to restore fine manual control after stroke. The goal of this study is to evaluate a new intervention that would combine targeted electrical stimulation of selected nerves with use a soft, pneumatically actuated hand exoskeleton to enhance repetitive practice of independent movements of the fingers and thumb in order to improve rehabilitation of hand function after stroke.
The investigators will recruit stroke survivors in the subacute phase of recovery (2-18 months post-stroke). These participants will be involved in a 5-week intervention involving 15 training sessions. During these sessions, participants will train independent movement of the digits of the paretic hand. Evaluation of motor control of the paretic hand will occur prior to initiation of training, at the midpoint of the training period, after completion of training, and one month later.
Interested in participating?
Request Info21 year and older
All sexes
Interventional
Not applicable
Raleigh, North Carolina, 27695, United States
Location status: Recruiting
Derek Kamper, PhD
CONTACT
Mohammad Ghassemi, PhD
CONTACT
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
The participant controls an avatar hand by the movement of their own digits. Each avatar digit corresponds to a given virtual key. "Sufficient" digit flexion results in "playing" of that key, with visual and auditory feedback of key strike. Participants will wear a soft exoskeleton, the PneuGlove, with embedded bend sensors to provide real-time measurement of digit flexion. Pneumatic resistance to flexion can be applied to each digit independently, along with extension assistance, through air chambers running through the glove. The FES is intended to assist finger flexion by activating extrinsic finger flexor muscles. A high-density 2×8 stimulation electrode grid will be placed over the median and ulnar nerves at the medial side of the upper arm. The stimulator can deliver electrical stimulation to any pair of electrodes. At the beginning of each session, the investigators will identify the electrode pairs which best produce flexion of each digit with minimal discomfort.
Traditional occupational therapy training sessions.
Time frame: Change of value from before the intervention to immediately after the intervention.
A standardized and objective measure of fine and gross motor hand function using simulated activities of daily living.
Time frame: Change of value from before the intervention to immediately after the intervention.
Force produced when the thumb pinches against the radial side of the index finger as if holding a key.
Time frame: Change of value from before the intervention to immediately after the intervention.
Force produced when thumb pinches against the tips of the index and middle fingers.
Time frame: Change of value from before the intervention to immediately after the intervention.
Touch sensitivity will be measured with von Frey hairs (Aesthesio®).
Time frame: Change of value from before the intervention to immediately after the intervention.
A quick, simple and inexpensive test to measures unilateral gross manual dexterity.
Time frame: Change of value from before the intervention to immediately after the intervention.
A standardized, quantitative assessment used to measure finger dexterity.
Contact information is provided by the study sponsor or research team.
Derek G Kamper, PhD
CONTACT
Mohammad Ghassemi, PhD
CONTACT
North Carolina State University
Other
A Multimodal Intervention to Improve Manual Dexterity in Subacute Stroke Survivors
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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