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NCT Number: NCT07014111

Fight Fatigue: A Progressive Muscle Relaxation and Walking Intervention to Reduce Fatigue in Adults With ESKD

Fight Fatigue is evaluating the feasibility and acceptability of a combined progressive muscle relaxation and walking intervention to reduce fatigue for adults with end-stage kidney disease receiving in-center hemodialysis.

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Key information

Conditions

End Stage Renal Disease on Dialysis Fatigue Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

UI Health/University of Illinois Chicago

Chicago, Illinois, 60612, United States

Location status: Recruiting

Location contact

Mary Hannan

CONTACT

[email protected]

312-355-4838

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of ESKD diagnosis and receiving hemodialysis for at least 3 months
  • Can read and speak English
  • Fatigue measured via visual analogue scale, score ≥4 over the last week
  • Able to stand and walk one block
  • Has a cell phone that can receive text messages

Exclusion criteria

  • Patient's nephrologist refuses for them to participate
  • Unstable angina
  • Unstable pulmonary disease or pulmonary symptoms that preclude participation
  • Lower-extremity amputation without prosthetic (BKA, AKA) -Orthopedic or neurologic condition that would preclude walking or tensing/releasing of muscles-
  • Cognitive impairment that, in the judgement of the research team, precludes trial participation
  • Participation in the formative phase of the development of Fight Fatigue

Treatment and study plan

Fight Fatigue

Behavioral

Combined progressive muscle relaxation and walking (increasing step count) 12-week intervention that consists of education/training followed by text messages.

Attention Control

Other

End-stage kidney disease education

Primary outcomes

  1. Feasibility of recruitment

    Time frame: Baseline to week 12

    Recruitment metrics (enrolled/invited)

  2. Feasibility of retention

    Time frame: Baseline to week 12

    Retention in the study from baseline to week 12

  3. Acceptability

    Time frame: End of study (Week 12)

    Participant rating of acceptability (e.g., enjoyable, easy to understand) via Likert scale questions and open ended questions

  4. Adherence to the study protocol

    Time frame: Baseline to week 12

    Adherence to the intervention measured with adherence to step counts, number/duration of accesses on the study-specific website, and adherence to study procedures as evaluated with number of text messages read/sent messages read.

Other outcomes

  1. Fatigue

    Time frame: Baseline to week 12

    FACIT-Fatigue measure

Study contacts

Contact information is provided by the study sponsor or research team.

Mary Hannan, PhD

CONTACT

[email protected]

3123554838

Sponsors and collaborators

Lead sponsor

University of Illinois at Chicago

Other

Collaborators

  • National Center for Complementary and Integrative Health (NCCIH)

Registry information

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Jun 10, 2025
Registry last updated
Sep 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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