Fiber Tolerance Study

Inclusion criteria

• Age ≥ 45 and ≤ 70 years
• Body Mass Index (BMI) ≥ 18.5 and ≤ 29.9 kg/m2
• Signed consent form
• Willingness and ability to comply with the protocol
• Good general health
• Defecation frequency: between three bowel movements per week and three bowel movements per day within a month for screening.

Exclusion criteria

• Presence or history of chronic gastrointestinal disorders (e.g. stomach ulcers, ulcerative colitis, Crohn's disease) or history of abdominal surgery with resection of the bowel (small or large intestine).
• Presence of other medical conditions where gastrointestinal function often/probably is affected, such as:

• autoimmune diseases (e.g. diabetes mellitus type I, multiple sclerosis, systemic lupus erythematosus).
• eating disorders (e.g. anorexia nervosa, bulimia nervosa, binge eating disorder).
• intestinal/gastrointestinal disorder due to a stroke.
• Chronic diseases (including but not limited to hypertension, dyslipidaemia, type 2 diabetes mellitus, thyroid disorders) that cannot be controlled with the use of medication/therapy.
• Severe acute liver disease or chronic liver disease.
• Severe or chronic kidney disease or need for hemodialysis.
• Colonoscopy, irrigoscopy or other bowel cleansing, or other surgical procedures related to the gastrointestinal tract (eg. colon polypectomy, appendectomy) or for which use of systemic antibiotics within 1 month before the screening is required or scheduled during participation in the study.
• Use of enemas, laxatives, antacids, proton pump inhibitors, prokinetics (e.g. metoclopramide, drugs that affect motility), digestive enzymes, narcotic/morphine analgesics within 1 week prior to screening or intended use during participation in the study.
• Following a vegetarian or vegan diet.