Fertility Outcomes of Ovarian Tissue Cryopreservation

With the advancement of assisted reproductive technology, more young cancer patients can consider having children. Ovaries and testes are important reproductive organs, and drugs, diseases, chemotherapy, and radiotherapy can all damage them. Reproductive preservation technology aims to protect patients whose reproductive ability has been damaged due to gonadotoxic drug therapy. Women can preserve their reproductive ability by freezing ovarian tissue cryopreservation so that they can have children in the future. Patients who have undergone or will undergo ovarian tissue cryopreservation in Hong Kong Children's Hospital will be invited to participate in the study. Here, we aim to evaluate the outcomes after ovarian tissue cryopreservation.

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Key information

Conditions

Neoplasms

Age range

0 year–18 year

Sex eligibility

Female

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients aged from 0-18 years old and diagnosed with cancer
Patients who have undergone or will undergo ovarian tissue cryopreservation in Hong Kong Children's Hospital
For patients under 18 years old, parents/legal guardians will be asked to further sign the consent for them.

Exclusion criteria

Patients unable to provide consent/assent (i.e. significant psychiatric problems/cognitive delay)
Male patients

Treatment and study plan

Ovarian tissue freezing and subsequent auto-transplantation after thawing

Other

Removal of the ovarian tissue will be retrieved via laparoscopic surgery under general anesthesia. The ovarian cortical tissue obtained will be transferred on ice to the laboratory for cryopreservation. After medical treatment, if the patient would like to start a family but has experienced premature ovarian failure, she will have ovarian tissue auto-transplantation after thawing.

Primary outcomes

Surgical complications

Time frame: 15 years

Surgical complications after ovarian tissue transplantation
Pregnancy rate

Time frame: 15 years

Pregnancy rate after ovarian tissue transplantation

Study contacts

Contact information is provided by the study sponsor or research team.

Elaine Ng

CONTACT

[email protected]

35052745

Sponsors and collaborators

Lead sponsor

Chinese University of Hong Kong

Other

Registry information

Important dates

Study start: 2026
Primary completion: 2031
Study completion: 2032
First posted: Jan 14, 2026
Registry last updated: Jan 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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