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Completed

NCT Number: NCT04805697

Fermented Grape Combined With Fruits and Vegetables Drink on Anti-aging and Anti-inflammatory

60 subjects were recruited and divided into placebo group and fermented grape drinks group.

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Key information

Conditions

Skin Condition Skin Diseases Skin and Connective Tissue Diseases

Age range

20 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Research & Design Center, TCI CO., Ltd

Taipei, 100225, Taiwan

About this study

In this study, using a fermented grape drinks made of fermented grapes with fruit and vegetable powder to explore whether it can improve the skin's condition and achieve anti-inflammatory effects. Sixty subjects were recruited and divided into placebo group and fermented grape drinks group. After drinking for 8 weeks, skin test and blood biochemical analysis were performed.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Dry skin.
  • Rough skin
  • Large pores
  • Dark yellow complexion
  • Sagging skin

Exclusion criteria

  • Skin disorders
  • Liver diseases
  • Kidney diseases
  • Allergy to cosmetics, drugs, or foods
  • Pregnant and lactating women
  • People who had any cosmetic procedures before 4 weeks of the study
  • Area of facial spot over 3 cm2
  • Vegan
  • People who took collagen supplements in the past 3 months.

Treatment and study plan

Placebo Group

Dietary Supplement

subjects drank 50 ml , 1 bottle a day for 8 week

fermented grape drinks

Dietary Supplement

subjects drank 50 ml , 1 bottle a day for 8 week

Primary outcomes

  1. skin brightness

    Time frame: 8 week

    The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then using corneometer CM825 to examine skin brightness (The higher the value, the more water content, C.U., corneometer units )

  2. skin elasticity

    Time frame: 8 week

    The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then using cutometer dual MPA580 to examine skin elasticity (The closer the R2 value is to 1, the better the elasticity and no unit)

  3. skin moisture

    Time frame: 8 week

    The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then using probe system GL2000 & MPA10 to examine skin moisture (The higher the value, the higher the gloss, no unit)

  4. skin spot

    Time frame: 8 week

    The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then usig VISIA-CR to examine skin spot (The higher the value, the larger the pore area, mm2)

  5. skin wrinkle

    Time frame: 8 week

    The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then using VISIOSCAN-VC20 to examine skin wrinkle (The higher the value, the more wrinkles, surface evaluation of wrinkles, SEW)

  6. inflammatory cytokines

    Time frame: 8 week

    The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then using ELISA kit to examine inflammatory cytokines (pg/ml)

Sponsors and collaborators

Lead sponsor

TCI Co., Ltd.

Industry

Registry information

Official study title

Fermented Grape Drinks Made of Fermented Grapes With Fruit and Vegetable Powder to Explore Whether it Can Improve the Skin's Condition and Achieve Anti-inflammatory Effects.

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Mar 18, 2021
Registry last updated
Mar 22, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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