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Completed

NCT Number: NCT07268911

Femoral Rami Obturator Nerve Trunk (FRONT) Block in Intramedullary Nail Surgery .

The study propose that using femoral rami obturator nerve trunk(FRONT) block may help postoperative analgesia in nail femur surgeries. The technique is relatively new, introducing one needle to target two nerve blocks in the same entry point. The block spare motor fibers of femoral nerve so it may help both early mobilization and effective analgesia, which in turn enhance early recovery and better outcomes.

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Key information

Age range

60 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Qena University

Qina, Qena Governorate, 83511, Egypt

About this study

Post operative pain levels after hip fracture are high during ambulation and may worsen outcome after hip fracture. Regional anesthesia has shown to facilitate rehabilitation in orthopedics procedures. Many of these regional anesthesia techniques ,such as femoral nerve, lumber plexus, peri capsular nerve group(PENG), fascia iliaca blocks have gained attention for their opioid and some times for motor sparing potential, as well as the ability to provide targeted analgesia for anterior hip joint. Nevertheless the anterior hip joint coverage needs the constant contribution of femoral and obturator nerves to provide adequate pain relieve. In this study patients will receive preoperative femoral rami obturator nerve trunk(FRONT) block , a novel regional anesthesia technique described by Jessen et al., as a promising solution to the long-standing challenge of anesthetizing both the femoral and obturator nerve branches in anterior hip joint for postoperative pain control, addressing a more comprehensive coverage of anterior hip innervation.

Note: The protocol was amended prior to enrollment of the reported cohort. The control group was changed from multimodal analgesia alone to a sham block procedure; the primary outcome was changed from postoperative NRS pain score to time to first analgesic request; motor assessment was expanded from the Modified Bromage scale to include Manual Muscle Testing (MRC scale) and straight leg raise.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • the elderly age≥60 years
  • American Society of Anesthesiologists (ASA) classification 1-2
  • patients who undergoing surgery for intramedullary nail surgery.

Exclusion criteria

  • patient refused to participate and consent
  • patients with a history of mild cognitive impairment (MCI), dementia, and delirium
  • patients with known preoperative infections (pulmonary infection, urinary infection, and sepsis).
  • coagulopathy

Treatment and study plan

Femoral rami obturator nerve trunk (FRONT) block

Procedure

ultrasound-guided FRONT block will be performed at the infrainguinal level, targeting the iliopsoas plane. Using the same needle approach, the subpectineal compartment will be also accessed . We will use ultrasound and electrical nerve stimulation guidance (0.4 mA, 0.1 ms, without eliciting a motor response) to avoid direct involvement of the femoral nerve. A total of 40 mL (20 mL for the iliopsoas plane and 20 mL for the subpectineal compartment) of 0.125% plain levobupivacaine will be administered.

Sham Block

Procedure

Sham Control: Patients underwent an identical ultrasound-guided needle insertion procedure at the same anatomical sites and technique of FRONT block (iliopsoas plane and subpectineal compartment) with injection of an equivalent volume of placebo drug in the form of normal saline.

Primary outcomes

  1. Time to first postoperative analgesic request

    Time frame: [Time Frame: up to 36 hours postoperatively]

    Description: Time in hours from spinal anesthesia to the first patient request for rescue analgesia (IV nalbuphine or ketorolac, administered when NRS > 4).

Secondary outcomes

  1. Opioid consumption

    Time frame: When 36 hours postoperatively has passed.

    First analgesic request time and total opioid consumption will be recorded

  2. Modified Bromage score

    Time frame: Patients will be followed for 36 hours postoperatively and assessed for motor function at 2, 4, 6, 12, 18, 24, 36 hours.

    assessed using Modified Bromage scale after spinal anesthesia has been resolved, where score 0 means full movement, and 4 means complete motor loss.

  3. Complication

    Time frame: Patients will be followed for 36 hours postoperatively and assessed for presence of any complications or side effects at 2, 4, 6, 12, 18, 24, 36 hours

    any complication either surgical or side effects will be recorded (vomiting, allergy, urinary retention, etc.)

  4. Numeric Rating Scale (NRS)

    Time frame: Time Frame: 2, 4, 6, 12, 18, 24, 36 hours postoperatively]

    Score from 0 = no pain at all to 10= worst pain imaginable, both at rest and movement

  5. Manual Muscle Testing (MRC scale)

    Time frame: Time Frame: 2, 4, 6, 12, 18, 24, 36 hours postoperatively

    Quadriceps strength graded manually against examiner resistance using the Medical Research Council (MRC) 0-5 scale, performed by the blinded outcome assessor.

  6. Straight Leg Raise (SLR) test

    Time frame: [Time Frame: 2, 4, 6, 12, 18, 24, 36 hours postoperatively]

    Description: Ability to actively raise the extended leg off the bed, assessed as a functional indicator of quadriceps/hip flexor motor recovery, performed by the blinded outcome assessor.

Sponsors and collaborators

Lead sponsor

South Valley University

Other

Registry information

Acronym: FRONT block

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 8, 2025
Registry last updated
Jul 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.