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NCT Number: NCT07329205

Femoral Nerve Mobilization for Patients With Knee Osteoarthritis

Background: Knee osteoarthritis (KO) is considered as a cause of disability among the elderly, causing pain, reduced quality of life, and decreased functionality. There is a limited knowledge about using femoral nerve mobilization in treating patients with arthritic changes.

Objectives: This study will be designed to determine the efficacy of adding of femoral nerve mobilization on pain intensity, function, quality of life and central sensitization in patients with knee osteoarthritis Methods: Thirty patients (aged ≥50 years with KO Kellgren-Lawrence grades I-II) will be included in this study: Patients will randomly be assigned into two groups: group A will receive traditional physical therapy while group B will receive femoral nerve mobilization in addition to traditional physical therapy. Three sessions will be performed for four weeks by 3 session /week. Patients will be evaluated for pain intensity using the numerical rating scale (NRS), knee function by WOMAC scale, quality of life by 12-item Short Form Survey questionnaire (SF-12) and central sensitization by the Arabic version of central sensitization inventory (CSI).

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Key information

Conditions

Knee Osteoarthristis Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Osteoarthritis, Knee Rheumatic Diseases

Age range

50 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Prince Sattam bin Abdulaziz University

Al Kharj, 16242, Saudi Arabia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients aged 50 years or older, diagnosed with KO according to theAmerican College of Rheumatology's criteria with knee pain, and grade I or II on the Kellgren-Lawrence radiographic scale

Exclusion criteria

  • individuals suffering from chronic conditions considered to be perpetuating factors (e.g., fibromyalgia)
  • those with conditions causing lower extremity pain
  • individuals who had taken analgesics within 24 h before evaluations
  • those who had undergone corticosteroid or local anesthetic infiltration in the year prior to the study or during the follow-up period
  • those using substances that could interfere with treatment
  • those with a previous diagnosis of neuropathy (lumbosacral plexus) or myopathy
  • those with contraindications to mobilization or exercise, and those with cognitive deficits (dementia, Alzheimer's).

Treatment and study plan

Traditional Physical therapy

Other

stretching exercises for hamstring, calf muscles and iliotibial band in addition to isotonic exercise for hip extensors and abductors and isometric quadriceps exercise

Femoral nerve mobilization

Other

A physiotherapist guided the patients in performing active mobilization of the femoral nerve. The prescribed method for active neural mobilization involved assuming a prone position supported by the forearms with a slight extension of the spine, flexion of the knee, and extension of the cervical spine. This was followed by performing the opposite movement

Primary outcomes

  1. pain intensity

    Time frame: after 4 weeks

    The pain was assessed by the numerical rating scale (NRS) where zero indicating no pain and 10 indicating maximal pain

  2. central sensitization

    Time frame: after 4 weeks

    The CSI is a validated questionnaire designed to identify symptoms associated with central sensitization. It has two components: Scale A assesses 25 common symptoms in individuals with central sensitization, resulting in a score ranging from 0 to 100. This score was interpreted as follows: subclinical (0-29), mild (30-39), moderate (40-49), severe (50-59), and extreme (60-100). Scale B, which is not scored, collects information on previous diagnoses of specific diseases

Study contacts

Contact information is provided by the study sponsor or research team.

Mohammed Hegazy, Phd

CONTACT

[email protected]

00966566169893 ext. 00966115886387

Sponsors and collaborators

Lead sponsor

Prince Sattam Bin Abdulaziz University

Other

Registry information

Official study title

Effects of Femoral Nerve Mobilization on Pain Intensity, Function, Quality of Life and Central Sensitization in Patients With Knee Osteoarthritis

Acronym: RCT

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jan 9, 2026
Registry last updated
Jan 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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