Fecal Microbiota Transplantation As a Potential Treatment for Parkinson's Disease

Fecal microbiota transplantation (FMT) is a technique in which intestinal microbiota are transferred from a healthy donor to the patient, with as primary goal to introduce - or restore - a stable and 'healthy' microbial community in the gut.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms and Gastrointestinal dysfunction, in particular constipation, affects up to 80% of PD patients and may precede the onset of motor symptoms by years.

this study include one group of PD patients that will receive FMT. two other groups will serve as controls:

• PD patients that will not receive FMT
• healthy people who live with PD patients in the same house and share similar surrounding

Inclusion criteria

• Subjects aged > 50 years, diagnosed as suffering from PD and under follow up of the Movement Disorders Clinic in Soroka University Medical Center.
• Subjects complaining of constipation .
• Subjects who did not perform a screening colonoscopy for colon cancer.
• Subjects who are clinically undertreated according to last Movement Disorders specialist's impression at the clinic visit.

Exclusion criteria

• Subjects who do not complain of constipation or seem clinically stable properly treated pharmacologically.
• Subjects who already underwent a screening colonoscopy for colon cancer.
• Subjects who suffer from a cognitive decline and could not give their consent, or patients who refuse to undergo a colonoscopy.