Features of the Clinical Course and Prognosis in Patients With Idiopathic Pulmonary Hypertension When Using Modern Strategies of Specific Therapy

This study will be performed based on a retrospective analysis of the cases of 150-170 patients with IPAH observed at the Research Institute of Clinical Cardiology over the past 10 years, for a comparative assessment of the survival of groups of patients with IPAH diagnosed in the period 2004-2013 and 2014-2023.

The demographic, clinical, functional, hemodynamic characteristics of patients, comorbidity, blood biomarker levels, received PAH-specific and symptomatic therapy will be assessed in order to determine the clinical characteristics of patients with IPAH.

The prospective part of study will include 50 patients with IPAH.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Idiopathic Pulmonary Arterial Hypertension Familial Primary Pulmonary Hypertension Hypertension, Pulmonary Lung Diseases Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Russian National Cardilogy Reasearch Center

Moscow, 121552, Russia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age over 18 years;
verified diagnosis of IPAH

Exclusion criteria

age under 18 years;
Other etiology op PAH,
ischemic heart disease confirmed by MSCT of the coronary arteries or coronary angiography;
diseases of the musculoskeletal system that prevent 6MWT
severe liver dysfunction (more than 9 points on the Child-Pugh scale, class C)
severe renal dysfunction (CC less than 15 ml/min), need for hemodialysis

Treatment and study plan

Primary outcomes

Mortality in 3 years after diagnosed IPAH

Time frame: 3 years

Sponsors and collaborators

Lead sponsor

Russian Cardiology Research and Production Center

Other

Registry information

Official study title

Features of the Clinical Course and Prognosis in Patients With Idiopathic Pulmonary

Important dates

Study start: 2023
Primary completion: 2024
Study completion: 2025
First posted: Sep 19, 2024
Registry last updated: Sep 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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