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Completed

NCT Number: NCT02423499

Features Emotional Responses in Adults With Autism: Comparison With Bipolar Disorder (REMBAU)

The objective of this study is to identify the specific characteristics of Autism Spectrum Disorder (ASD) in emotional response profiles and shared with Bipolar Disorder (BD) characteristics.

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Key information

Conditions

Autism Spectrum Disorder Bipolar Disorder Bipolar and Related Disorders Child Development Disorders, Pervasive Mental Disorders Mood Disorders Neurodevelopmental Disorders

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

LEMAIRE

Tours, 37044, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • For all participants:
  • Age between 18 and 50 years
  • Normal vision (or corrected)
  • Absence of neurological disorder (epilepsy , head trauma, ... )
  • Ability to understand information about the protocol
  • Informed and signed consent
  • normal mood (euthymia)
  • normal or high intelligence
  • Subjects with ASD:
  • Subjects with an autism spectrum disorder according to the DSM-5
  • The diagnosis is confirmed by diagnostic interviews: ADI- R (Autism Diagnostic Interview-Revised) and / or ADOS (Autism Diagnostic Observation Schedule ) .
  • Subjects with bipolar disorder:
  • Diagnosis of bipolar disorder according to DSM-IV-TR or DSM -5
  • The diagnosis is confirmed by the MINI 6.0 (The Mini-International Neuropsychiatric Interview) .
  • Healthy volunteers:
  • Inclusion after checking the national register of healthy volunteers
  • No history of disease of the central nervous system or psychiatric disorder
  • No family history of ASD or BD in the first degree
  • Lack of psychotropic medication or current cardiotropic
  • Lack of psychiatric disorder on Axis I MINI 6.0
  • AQ Score < 32

Treatment and study plan

Primary outcomes

  1. Physiological emotional response during emotion elicitation in a laboratory session (Pupil size measured by eye tracking, heart rate, electrodermal response, breath rate) during emotion elicitation in a laboratory session

    Time frame: average 1 hour

Secondary outcomes

  1. Subjective emotional response during emotion elicitation in a laboratory session

    Time frame: average 1 hour

  2. Facial emotional response during emotion elicitation in a laboratory session

    Time frame: average 1 hour

  3. Experience sampling method in real life during a week (emotions, activities, social context, burden)

    Time frame: within the first 7 days after inclusion

  4. Physiological emotional response in real life (heart rate, electrodermal response, breath rate, actimetry)

    Time frame: within the first 24h approx. after inclusion

Sponsors and collaborators

Lead sponsor

University Hospital, Tours

Other

Registry information

Official study title

Features Emotional Responses in Adults With Autism: Comparison With Bipolar Disorder

Acronym: REMBAU

Important dates

Study start
2015
Primary completion
2021
Study completion
2021
First posted
Apr 22, 2015
Registry last updated
Jun 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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