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NCT Number: NCT07234799

Feasibility Testing of a Dyadic Exercise Program for Patients Undergoing Thoracic Radiotherapy and Their Family Caregivers

The goal of this study is to examine the feasibility and acceptability of an exercise intervention for patients undergoing thoracic radiation and their family caregivers.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The University of Texas M. D. Anderson Cancer Center

Houston, Texas, 77030, United States

Location status: Recruiting

Location contact

Kathrin Milbury, MA,PHD

CONTACT

[email protected]

713-745-2868

Kathrin Milbury, MA,PHD

PRINCIPAL_INVESTIGATOR

About this study

Primary Objectives:

  • Examine the feasibility and acceptability of an exercise program
  • Examine an initial sign for intervention efficacy by examining pre/post-test scores for patients' objective physical function and patient and caregiver subjective physical and mental quality of life.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Be diagnosed with a non-small cell lung cancer or esophageal cancer and going to receive at least 24 fractions thoracic RT
  • Have an ECOG performance status of ≤2
  • Have a family caregiver (e.g., spouse, sibling, adult child) willing and able (self-identified) to participate in the exercise program

Both patient and caregiver must meet all the following criteria:

  • Be ≥18 years old
  • Be able to read and speak English
  • Be able to provide informed consent

Exclusion criteria

  • A patient who meets the following criteria will be excluded from participating in this study:
  • Cognitive deficits noted in the medical records and/or cognitive deficits that would impede the completion of self-report instruments as deemed by the patient's attending radiation oncologist.
  • Experiences contraindications to exercise as determined by the clinical team
  • Regularly (self-defined) participates in an exercise program in the year prior to diagnosis

A patient and caregiver who is pregnant (medical notes and/or self-identified, respectively) will be excluded.

Treatment and study plan

Exercise

Other

Study participants will engage in 7-10 exercises per session targeting major muscle groups (e.g. quadriceps, hamstrings, glutes, back, chest, arms, abdominal muscles). Movements will alternate between the lower and upper body thus allowing ample time for muscle-group recovery between exercises.

Primary outcomes

  1. Quality of Life Questionnaire

    Time frame: Through study completion; an average of 1 year

    Patients and caregivers will complete the Medical Outcomes. Study 36-item short-form survey (SF-36) assessing 8 distinct domains of QOL

Study contacts

Contact information is provided by the study sponsor or research team.

Kathrin Milbury, MA,PHD

CONTACT

[email protected]

(713) 745-2868

Sponsors and collaborators

Lead sponsor

M.D. Anderson Cancer Center

Other

Registry information

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
Nov 18, 2025
Registry last updated
May 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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