Feasibility Study of a Remote Behavioral Dietary Intervention in Patients With Early to Intermediate AMD: Glucose Lowering for Vision Extension

The primary goal of the study is to test dietary intervention at glycemic control and carotenoid levels in participants with intermediate age-related macular degeneration.

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Key information

Conditions

Age-Related Macular Degeneration Eye Diseases Macular Degeneration Retinal Degeneration Retinal Diseases

Age range

55 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of California, Los Angeles

Los Angeles, California, 90095, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Diagnosis of early to intermediate AMD with no history of retinal geographic atrophy (cRORA) or exudative disease
Eating a diet less healthy than average (Healthy Eating Index [HEI] score <61) based on 3 24-hour dietary recalls
Access to a computer or smart phone for use in the behavioral meetings (we will provide loaners for those lacking a smart phone
Because the initial questionnaires (ASA24), surveys and informed consent will be on line and in English, only individuals with fluency in English will be included. (They do not need to list English as their primary language.)

Exclusion criteria

HbA1c greater than 6.5%,
Diabetes or medications used to treat diabetes or obesity (including GLP1 agonists, metformin, glyburide
Use of statins, niacin or other lipid/cholesterol modifying medications
Recent cancer (within past 3 years)
Other retinal or ocular pathology (other than pseudophakia and/or refractive error (between -8 to +8 diopter spherical equivalence)

Treatment and study plan

Low glycemic Mediterranean diet behavioral modification

Behavioral

Participants will meet with behavioral interventionists to receive guidance on diet initially for 2 hours and then every month for one hour

Primary outcomes

Success rate of the diet behavioral modification

Time frame: baseline through one year

Success rate of the behavioral modification of the diet based on self-reported assessments and in association with systemic markers of improved health due to dietary modifications.

Continuous glucose monitoring measurements will be used to determine the proportion of time glucose >140 mg/dL for 24 hr/day for two weeks at each visit.

The definition of success will be halving the time glucose is >140 mg/dL.

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Collaborators

National Eye Institute (NEI)

Registry information

Official study title

Nonrandomized, Unmasked Feasibility Study of a Remote-based Behavioral Dietary Intervention in Patients With Early to Intermediate AMD: Glucose Lowering for Vision Extension (GLOVE)

Acronym: GLOVE

Important dates

Study start: 2026
Primary completion: 2028
Study completion: 2028
First posted: May 26, 2026
Registry last updated: May 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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