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NCT Number: NCT04172753

Feasibility of Online MR-guided Radiotherapy on a 1.5T MR-Linac

This study investigates the feasibility of imaging and treatment on a novel 1.5 T MR-Linac radiotherapy hybrid device.

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Key information

Conditions

Rectal Cancer Breast Cancer Breast Diseases Breast Neoplasms Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Esophageal Cancer Esophageal Diseases Esophageal Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Genital Diseases Genital Diseases, Male Genital Neoplasms, Male Head and Neck Cancer Head and Neck Neoplasms Intestinal Diseases Intestinal Neoplasms Liver Cancer Liver Diseases Liver Neoplasms Male Urogenital Diseases Neoplasms Neoplasms by Site Oligometastasis Prostate Cancer Prostatic Diseases Prostatic Neoplasms Rectal Diseases Rectal Neoplasms Skin Diseases Skin and Connective Tissue Diseases Urogenital Diseases Urogenital Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

Novel hybrid devices combine magnetic resonance imaging (MRI) and a linear accelerator in a single device. The superior soft tissue contrast compared with cone-beam computed tomography based treatment and the possibility for daily plan adaptation promise a higher precision of treatment, better target volume coverage and normal tissue sparing. In a first step the present study will test the feasibility of imaging and treatment on the 1.5 T MR-Linac.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • existing indication for radiation therapy
  • minimum age 18 years, no upper age limit
  • capacity for consent
  • Informed consent

Exclusion criteria

  • contraindication for MRI (claustrophobia, metallic implants not applicable for MRI
  • pregnancy

Treatment and study plan

Radiotherapy on the MR-Linac

Radiation

Radiotherapy is performed on the 1.5 T MR Linac

Imaging on the MR Linac

Diagnostic Test

Only imaging performed on the MR Linac

Primary outcomes

  1. Feasibility of online MR guided Radiotherapy

    Time frame: During every single patients treatment (i.e. between one to seven weeks after the first application of radiotherapy)

    Treatment of a patient is considered feasible when 85% of treatments were completed as planned in this patient

Secondary outcomes

  1. Time analysis

    Time frame: During every single patients treatment (i.e. between one to seven weeks after the first application of radiotherapy)

    Time required for online MR guided radiotherapy

Sponsors and collaborators

Lead sponsor

University Hospital Tuebingen

Other

Registry information

Official study title

Feasibility of Imaging and Radiotherapy on a Novel 1.5 T Hybrid Magnetic Resonance Imaging - Linear Accelerator System (MR-Linac)

Important dates

Study start
2018
Primary completion
2022
Study completion
2027
First posted
Nov 21, 2019
Registry last updated
Nov 21, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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