Feasibility of Intermittent Fasting During Chemotherapy

To test whether fasting is safe. 1) Explored by investigating adverse events from intermittent water-only fasting

To test whether fasting is safe. 2) by investigating changes in body weight throughout the treatment comparing the intervention and control groups.

Whether fasting is feasible. Explored in order to determine whether a larger trial can be successfully conducted in a similar setting with lymphoma patients fasting during cancer treatment.

Whether fasting is feasible. Explored in order to determine whether a larger trial can be successfully conducted in a similar setting with lymphoma patients fasting during cancer treatment.

Whether fasting is acceptable. Explored from a perspective of the participant, as the degree to which patients find the trial, its procedures, and its interventions agreeable, suitable, and satisfactory during chemotherapy treatment

Adverse events including number of infections, graded according to Common Terminology Criteria for Adverse Events

Evaluation of toxicity, including hematological toxicity and other relevant organ toxicities with blood test and using computer tomography (CT) or fluoro-deoxy-glucose positron emission tomography computer tomography (FDG-PET-CT)

By using EORTC QLQ-C30 questionnaire

The linguistic and content validation of the translated and culturally adapted Patient Generated Subjective Global Assessment (PG-SGA) will be utilized for gathering data on nutritional impact symptoms

Dietary intake 24 hours before and 24 hours after chemotherapy and the usual intake between chemotherapy cycles using food diary.

Bioelectrical impedance (BIA) will be used to collect data to explore changes in body weight, BMI and body composition.

In terms of numbers of readmissions, unplanned out- or inpatient visits, and days in the hospital

To better understand nutrition and metabolism related to fasting and cancer, we want to examine various biomarkers related to glucose, amino acid and fat metabolism, and inflammation, such as e.g. glucose, insulin, amino acids, triglycerides, C-reactive protein (CRP).

We will analyze the gut microbiota to explore the effect of fasting on the gut microbiota. We will collect feces samples at start and end of treatment to characterize the microbiota using high throughput sequencing.