Feasibility of Ethanolization of Vein of Marshall With Specific Catheter in Atrial Fibrillation Ablation

Inclusion criteria

• Suitable candidate for catheter ablation of atrial fibrillation defined as:

• history of symptomatic persistent atrial fibrillation
• Redo procedure for persistent AF or paroxysmal AF with isolated PV and no history of ethanol infusion in the VOM.
• Age > 18 years of both genders
• Patient affiliated or beneficiary of social security scheme
• Free, informed and written consent signed by the participant and the principal investigator (at least at the inclusion date and before all exams required for the clinical research)
• Effective contraception for women of childbearing potential

Exclusion criteria

• Minor
• Documented left atrial thrombus or another abnormality which precludes catheter introduction
• Contraindication to anticoagulation therapy (heparin, warfarin, or novel oral anticoagulant [NOAC]
• Contraindication to iodinated contrast product XENETIX® (iobitridol hypersensivity or at one of these excipients, history of major immediate reaction or cutaneous reaction to XENETIX® infusion, thyrotoxicosis)
• Hypersensitivity to ethanol
• Unstable angina or ongoing myocardial ischemia
• Myocardial infarction within 3 months prior to inclusion
• Congenital heart disease, where the underlying abnormality increases the ablation risk
• Severe bleeding, clotting or thrombotic disorder
• Pregnant, parturient or nursing women
• Unable or unwilling to provide written informed consent
• Patient detained by judicial or administrative order
• Patient under psychiatric care
• Patient admitted in a social or healthcare establishment for any purpose other than the research
• Subject to a legal protection order (guardianship, patient under legal protection)