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OpenTrials
Completed

NCT Number: NCT02792010

Feasibility and Reproducibility of T1 Rho MRI in the Evaluation of Hip Cartilage

Hip osteoarthritis is a frequent and invalidating disease. Early detection of cartilage modifications could provide better patient treatment. The T1rho MRI sequence allows the quantification of the cartilage signal that is correlated to modifications of the cartilage matrix, notably of the proteoglycans. The primary objective is to evaluate normal values of hip cartilage in vivo using T1rho MRI in healthy subjects and the reproducibility of the measurements. T1rho and T2 mapping sequences were acquired twice during the same session with 30 minutes interval to see if values were modified after a 30 minutes delay in a supine position. The secondary objective was to assess the correlation between T1rho and T2 values.

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Key information

Conditions

Healthy Volunteers

Age range

18 year–49 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hospices Civils de Lyon - Hôpital Edouard Herriot Pavillon B Radiologie

Lyon, 69437, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI <30
  • Accepting to participate in the study and signed the written informed consent
  • Covered by a health insurance system

Exclusion criteria

  • Pregnant woman or risk of pregnancy
  • MRI contraindication
  • Protected adults
  • Language barrier
  • Previous or current hip pain

Treatment and study plan

Hip cartilage MRI

Device

Hip cartilage MRI

Primary outcomes

  1. Quantification of the cartilage signal at T1rho MRI

    Time frame: Up to one month after inclusion (Visit 1)

    T1rho values of total hip cartilage and for each sub-region (mean, standard deviation, histogram)

Secondary outcomes

  1. Quantification of the cartilage signal at T1rho MRI

    Time frame: 15 (+/- 7) days after visit 1 (Visit 2)

    T1rho values of total hip cartilage and for each sub-region (mean, standard deviation, histogram)

  2. Quantification of the cartilage signal at T2 MRI

    Time frame: Up to one month after inclusion (Visit 1)

    T2 values of total hip cartilage and for each sub-region (mean, standard deviation, histogram)

  3. Quantification of the cartilage signal at T2 MRI

    Time frame: 15 (+/- 7) days after visit 1 (Visit 2)

    T2 values of total hip cartilage and for each sub-region (mean, standard deviation, histogram)

  4. Presence of cartilage lesions

    Time frame: Up to one month after inclusion (Visit 1)

    Morphological sequence to determine focal lesions

  5. Presence of cartilage lesions

    Time frame: 15 (+/- 7) days after visit 1 (Visit 2)

    Morphological sequence to determine focal lesions

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Acronym: CARHAT02

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Jun 7, 2016
Registry last updated
May 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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