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NCT Number: NCT05676450

Feasibility and Clinical Utility of Cell-free DNA (cfDNA) in Identifying Actionable Alterations and Minimal Residual Disease for Lymphoma Patients Across Community Centers in Texas

To test the feasibility of collecting cell-free DNA (cfDNA) samples from DLBCL patients before and after treatment. cfDNA is DNA traveling in your blood outside of a cell and is easily collected from blood samples drawn using the vein puncture method.

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Key information

Conditions

Lymphoma Hemic and Lymphatic Diseases Immune System Diseases Immunoproliferative Disorders Lymphatic Diseases Lymphoproliferative Disorders Neoplasms Neoplasms by Histologic Type

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

MD Anderson Cancer Center, Houston, Texas, United States

Loading trial locations.

About this study

Primary Objective:

  • To determine the feasibility and clinical utility of ctDNA in identifying actionable alterations and minimal residual disease for lymphoma patients across community centers in Texas.

Secondary Objectives:

  • To provide useful prognostic information before treatment, assess molecular response at interim time points and residual disease at the end of therapy, and identify tumor-specific mutations
  • Levels of cfDNA and its association with both EFS and OS in patients receiving therapy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male/female patients who are at least 18 years of age on the day of informed consent signing.
  • Patients must have a histologically documented diffuse large B-cell lymphoma requiring therapy.
  • Provision of written informed consent for the study.
  • Pregnant women not included
  • Cognitively impaired adults are not included.

Exclusion criteria

None

Treatment and study plan

cell-free DNA

Diagnostic Test

Given by IV (vein)

Primary outcomes

  1. Overall Survival (OS)

    Time frame: through study completion; an average 1 year

Study contacts

Contact information is provided by the study sponsor or research team.

Chijioke Nze, MD

CONTACT

[email protected]

832-729-1752

Sponsors and collaborators

Lead sponsor

M.D. Anderson Cancer Center

Other

Registry information

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Jan 9, 2023
Registry last updated
May 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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