FCI in Post-operative Low Grade Gliomas

Standard clinical magnetic resonance imaging (MRI) is the mainstay of diagnosis in brain lesions. It is a powerful imaging technique for the non-invasive investigation of the brain and has been an incredibly successful technology since its commercialisation in the 1980s largely due to its excellent spatial resolution and ability to distinguish multiple tissues in multiple planes. When exogenous contrast agents are used, MRI can demonstrate the breakdown of the blood-brain barrier and provide additional physiological information.

However, standard MRI has limitations in determining the subtypes of tumours, which originate from different cells and therefore contain differing types of proteins. The aim of this project is to establish if there is a difference in the relaxometry (i.e., loss of MRI signal over time) characteristics of different brain lesions using Field Cycling Imaging (FCI), which is a new technology being developed at the University of Aberdeen.

FCI combines the use of a moderately high magnetic field with the ability to probe low magnetic fields so that one can preserve image resolution while also exploiting the high contrast present at low magnetic fields. This provides quantitative data on the molecular dynamics in the tissues, completely non-invasively.

For this study, the research team will use FCI to try to establish if there is a difference in the relaxometry characteristics of different low-grade gliomas. Ten patients with postoperative low grade glioma will be included. Each participant will be asked to undergo one FCI scan only. FCI images will be acquired on dedicated equipment, specifically built for the purpose of imaging human volunteers and patients. Participants will carry on receiving their routine clinical care before and after their scan.

Inclusion criteria

• Patients with post operative low-grade glioma.
• Capacity to give informed consent.
• Capacity to co-operate with the scanning procedures and duration.
• Age 16 and above.
• Participants who can pass through a 50 cm-diameter circular hoop to ensure they will be able to fit inside the scanner.
• Participants who meet the safety criteria for undergoing an MRI scan.
• Participants must be mobile enough to be positioned onto the FCI scanner couch.

Exclusion criteria

• MRI-incompatible conditions, as detected in the MRI safety screening form.
• Restrictions to mobility that would prevent the correct positioning in the scanner by trained research radiographer (e.g., severe kyphosis).
• Participants who are unable to give fully informed consent.
• Women who are pregnant.
• Participants who are unable to understand or communicate in English.
• Patients who suffer from claustrophobia.