Fatigue and Cognitive Dysfunction Due to Synaptopathy or Graft Versus Host (GVH) Disease in the Brain.

Patients undergoing allogenic stem cell transplantation are regularly followed up in the outpatient clinic at Karolinska University Hospital. Here, patients are offered participation the fatigue study measuring both fatigue and cognitive impairment systematically by international standard. Meanwhile liquor samples and advanced PET imaging techniques are available for these patients as part of a research project allowing extensive immunological and radio-morphological studies.

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Key information

Conditions

Fatigue Cognition Disorders Cognitive Dysfunction Graft vs Host Disease Immune System Diseases Mental Disorders Neurocognitive Disorders Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

20 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ksenia Boriskina

Stockholm, 14186, Sweden

Location status: Recruiting

Location contact

Ksenia Boriskina, MD

CONTACT

[email protected]

0812380675

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

PET images available retrospectively

Treatment and study plan

PET investigation

Radiation

Trial subjects will undergo two advanced PET investigations

Primary outcomes

To investigate the role of inflammation on synaptic density and glial cell activation as the cause of mental fatigue and cognitive dysfunction in survivors after alloSCT.

Time frame: 2024-2027

Analysis of PET imaging (both descriptive and radiokinetical) in combination with biological markers for neuroinflammation.

Sponsors and collaborators

Lead sponsor

Karolinska University Hospital

Other

Collaborators

Karolinska Institutet

Registry information

Official study title

Fatigue Och Kognitiv Dysfunktion Till följd av Synaptopati Eller Graft Versus Host (GVH) Sjukdom i hjärnan.

Important dates

Study start: 2023
Primary completion: 2027
Study completion: 2028
First posted: Jan 26, 2026
Registry last updated: Jan 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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