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Completed

NCT Number: NCT02264951

Fat-induced Release of GLP-1 in Humans

This study compared the incretin-releasing effect of C8-diet oil and tributyrin with that of 20 ml olive oil on a molar basis in human volunteers.

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Key information

Conditions

Type 2 Diabetes Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

About this study

A structured triglyceride (1,3-di-octanoyl-2-oleoyl-glycerol, called C8-diet oil), which upon digestion results in generation of two medium-chain fatty acids and 2-oleoyl-glycerol (2-OG), may lead to activation of GPR119 only, since medium fatty acids are poor agonists for fatty acid receptors.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Caucasian healthy male subjects
  • Body mass index (BMI) 19 to 25 kg/m2
  • Informed consent

Exclusion criteria

  • Anaemia
  • Diabetes mellitus
  • Gastrointestinal diseases or operations interacting with intestinal absorption

Treatment and study plan

Tributyrin

Dietary Supplement

a triglyceride containing three C4-acids

C8-diet oil

Dietary Supplement

a triglyceride containing 2 C8-fatty acids and one oleic acid at sn-2 position

Olive Oil

Dietary Supplement

a triglyceride containing mostly three oleic acids

Carrot

Dietary Supplement

mainly water and glucose

Primary outcomes

  1. plasma GLP-1

    Time frame: 2 hours postprandial

  2. plasma GIP

    Time frame: 2 hours postprandial

Secondary outcomes

  1. plasma insulin

    Time frame: 2 hours postprandial

  2. plasma PYY

    Time frame: 2 hours postprandial

  3. plasma glucose

    Time frame: 2 hours postprandial

  4. plasma neurotensin

    Time frame: 2 hour postprandial

  5. plasma CCK

    Time frame: 2 hour postprandial

Sponsors and collaborators

Lead sponsor

Glostrup University Hospital, Copenhagen

Other

Collaborators

  • University of Copenhagen

Registry information

Official study title

Short Fatty Acids-induced Release of GLP-1 in Humans

Important dates

Study start
2013
Primary completion
2013
Study completion
2014
First posted
Oct 15, 2014
Registry last updated
Oct 15, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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