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NCT Number: NCT06556433

Family-Based Financial Incentives Intervention for Smoking Cessation

The current study will conduct an RCT to evaluate the effectiveness of a family-based incentive intervention with Alaska Native/American Indian families. The experimental arm will be compared to a control arm on biochemically-confirmed smoking abstinence at 6- and 12-months post-intervention.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

Dyads will be stratified by the index participant's sex, and residence with family member, and by the family member's current smoking status then randomized to a no incentives control condition (n=328 dyads) or a 6-month incentive intervention (n=328 dyads).

All dyads will receive existing evidence-based cessation materials on treatment resources and social support strategies. The study will measure the index participant's smoking status in both study groups weekly during the first four weeks, and at three and six months. All participants, including support persons, will receive incentives when they complete each of the smoking status assessments. The intervention group will additionally receive individual rewards provided to the index participant for achieving verified smoking abstinence at each time point, to a maximum of $750.

The enrolled family member will also receive rewards equivalent to the value earned by the index participant that can contribute to family needs. The study will explore potential moderators (e.g., family member smoking status, index participant's sex) and mediators (e.g., interdependence) of intervention effects.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Index Participant Inclusion Criteria:

  • Alaska Native/American Indian (ANAI) person (based on self-reported race) and reside in Alaska.
  • Age ≥18 years.
  • Self-report smoking in the past 7 days, biochemically verified with saliva cotinine ≥ 30 ng/mL (positive result based on at-home saliva swab test provided by study team).
  • Smoked ≥ 3 cigarettes per day over the past 3 months.
  • Considering or willing to make a quit attempt.
  • Have or will nominate one adult family member to enroll with them.
  • Own or have access to a mobile phone or tablet with Internet and text messaging capabilities, or will be loaned an iPad for the study duration
  • Willing to upload photos of self during completion of smoking status tests.
  • Willing to complete and sign an Internal Revenue Service (IRS) W-9 tax identification form if they wish to receive payments on the study.
  • Willing to provide written informed consent and participate in study-related tests and procedures.

Index Participant Exclusion Criteria:

  • Already enrolled in the study with another family member.
  • Participated in a prior study phase.

Family Member Participant Inclusion Criteria (regardless of smoking status or residence with the index participant):

  • Age ≥18 years.
  • Defined as family and nominated by the index participant, or have an ANAI family member who is ≥18 years and smokes that they would like to support in quitting.
  • Own or have access to a mobile phone or tablet with Internet and text messaging capabilities, or will be loaned an iPad for the study duration.
  • Willing to complete and sign an IRS W-9 tax identification form if they wish to receive payments on the study.
  • Willing to provide written informed consent and participate in study related tests and procedures.

Both men and women, those from non-ANAI racial/ethnic groups, and those who live outside of Alaska in the United States will be eligible family member participants.

Family Member Participant Exclusion Criteria:

  • Already enrolled with another family member.
  • Participated in a prior study phase.

After the randomized controlled trial, qualitative interviews will be conducted with index participants, family member participants, and Alaska Tribal Health System Stakeholders to inform program implementation. Healthcare providers, cessation specialists, Elder advisors, and Tribal Health System leaders and stakeholders will be invited by the Alaska Native Tribal Health Consortium team and separately consented and interviewed.

Treatment and study plan

Financial Incentive Rewards

Behavioral

Participants in the Rewards Group will have abstinence reinforced through escalating financial incentives.

Primary outcomes

  1. Change in smoking status

    Time frame: 6 months, 12 months

    Number of participants to have biochemically verified, prolonged smoking abstinence.

Study contacts

Contact information is provided by the study sponsor or research team.

Audrey G McGuinness, BA

CONTACT

[email protected]

1-507-422-5074

Christi A Patten, PhD

CONTACT

[email protected]

507-261-0718

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Collaborators

  • Alaska Native Tribal Health Consortium
  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

Alaska Native Family-Based, Financial Incentives Intervention for Smoking Cessation: An RCT

Acronym: Aniqsaaq-RCT

Important dates

Study start
2024
Primary completion
2028
Study completion
2028
First posted
Aug 16, 2024
Registry last updated
Feb 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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