Familial B-cell Lymphoproliferative Disorders

This study investigates families with at least two cases of B-cell lymphoproliferative disorders (LPD), and evaluates the prevalence of LPD in families, the relationship between medical history, genetic factors, and the risk of familial LPD, and various clinical outcomes for these families in a multiethnic population of Jews and Arabs in Israel.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Conditions

Lymphoproliferative Disorders Chronic Disease Chronic Lymphocytic Leukemia Disease Attributes Hematologic Diseases Hemic and Lymphatic Diseases Immune System Diseases Immunoproliferative Disorders Leukemia Leukemia, B-Cell Leukemia, Lymphocytic, Chronic, B-Cell Leukemia, Lymphoid Lymphatic Diseases Monoclonal B-Cell Lymphocytosis Neoplasms Neoplasms by Histologic Type Pathologic Processes Pathological Conditions, Signs and Symptoms Precancerous Conditions Premalignant

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient inclusion criteria:

Patients must have LPD and must have a family history of LPD. LPD patients who signed an informed consent to participate in the study.

Criteria for the inclusion of relatives of patients:

Relatives must be related by blood to LPD patients or unrelated (for control group).

Relatives who signed an informed consent to participate in the study.

Exclusion criteria

Pregnant women, special populations and those lacking judgment will not be included

Treatment and study plan

No intervention

Other

No intervention

Primary outcomes

Prevalence of familial LPD in Israel

Time frame: 5 years
Association between medical history and genetic variants and the risk of familial LPD

Time frame: 5 years
Risk of clinical outcomes among familial LPD and family members

Time frame: 15 years

Study contacts

Contact information is provided by the study sponsor or research team.

Geffen Kleinstern, PhD

CONTACT

[email protected]

+972545715624

Tamar Tadmor, MD

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

University of Haifa

Other

Collaborators

Bnai Zion Medical Center

Registry information

Official study title

Epidemiology of Familial B-cell Lymphoproliferative Disorders

Acronym: Familial_LPD

Important dates

Study start: 2024
Primary completion: 2028
Study completion: 2040
First posted: Feb 8, 2023
Registry last updated: May 8, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting