Skip to main content
OpenTrials
Completed

NCT Number: NCT05100407

Factors Impacting the Prevalence of MDR Bacteria

1. To determine the prevalence of multidrug resistance bacteria in patient with different infections 2. To evaluate patients' predictive risk factors of antimicrobial resistance 3. To assess the association between patients' factors and prevalence of MDR bacteria

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Multi-antibiotic Resistance

Sex eligibility

All sexes

Study type

Observational

Primary location

Faculty of pharmacy /kufa university

Najaf, Iraq

About this study

Antimicrobial resistance is one of the most critical public health issue in this century . WHO declared antimicrobial resistance as one of the top ten global health threats that impend the effective management and prevention of evolving infections .

Antimicrobial resistance nowadays poses a big challenge because of the emerging of resistance to the antibiotics that previously effective and development of multidrug resistance infections with subsequent increase in morbidity, mortality and financial loss .

In spite of WHO health strategies that taken to face multidrug resistance problem, the burden of antimicrobial resistance in Europe is compared with combined burden of influenza and HIVS .while in USA the estimated antibiotics resistance infections is 2.8 millions and the related deaths exceeded 35,000 every year and expected to reach to ten million deaths with collective cost of 100 trillion USD annually in 2050 .

Numerous studies reported that self-medications, improper prescription, overuse of antibiotics, deficiency of antibiotics susceptibility test and limited knowledge and attitude of population towards antibiotics are the main factors that lead to antibiotics efficacy being reduced with long hospital stay. Other studies stated that the predictive indicators of MDR tragedy are age, gender, comorbidities, previous hospital stay or antibiotic use .

In low and middle income countries like IRAQ there is a difficulty in estimation the scope of antibiotics resistance problem and its evolving over time due to the lack of surveillance, besides alarmingly excessive antibiotics consumption added other challenges and urged us to aim this study .

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients who were screened for MDR bacteria
  • patients who accepted to participate in the study

Exclusion criteria

  • patients with no growth media
  • patients who cannot communicated

Treatment and study plan

Primary outcomes

  1. Prevalence of multidrug resistance bacteria in isolated patient specimen

    Time frame: based line value (zero months)

    proportion of MDR bacteria that detected in isolated specimen

  2. Association of patient's factors with prevalence of multidrug resistance Bacteria.

    Time frame: based line value (zero months)

    exploring the association between patient's factors and the prevalence of MDR bacteria by multivariate analysis

Secondary outcomes

  1. Prevalence of Methicillin resistance staph. Aureus (MERSA)

    Time frame: based line value (zero months)

    proportion of participants with MERSA bacteria that detected in isolated specimen

  2. Prevalence of vancomycin (-resistant Enterococci VRE)

    Time frame: based line value (zero months)

    proportion of participants with VRE bacteria that detected in isolated specimen

  3. Prevalence of extended spectrum β lactamase producers (ESBL)

    Time frame: based line value (zero months)

    proportion of participants with ESBL bacteria that detected in isolated specimen

  4. Knowledge, attitude and practice (KAP) toward antibiotic use

    Time frame: based line value (zero months)

    the score indicator of KAP through a module of KAP survey by 20 categorized questions the knowledge is individual understanding about antibiotic resistance the attitude is the perceptions and beliefs that respondents (+),(-) perceive towards antibiotic resistance the practice is the observable actions of individual towards antibiotic use

  5. Risk factors for antibiotic resistance

    Time frame: based line value (zero months)

    asses patient's predictive factors and their role in prevalence of multidrug resistance bacteria

Sponsors and collaborators

Lead sponsor

Kufa University

Other

Registry information

Official study title

Evaluation of the Prevalence and Antibiotic Susceptibility Pattern of Multidrug Resistance Bacteria and Its Association With Patients' Predictive Factors

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Oct 29, 2021
Registry last updated
Aug 18, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.