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NCT Number: NCT05374460

Factors Affecting Sensory and Motor Learning

How participants perceive the position of their own hand in various contexts will be examined. This will include changing the visual display to suggest the hand is in a slightly different position, and asking participants to indicate where they think it is by pointing with their other hand.

Recruiting

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Key information

Conditions

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hannah Block

Bloomington, Indiana, 47403, United States

Location status: Recruiting

Location contact

Hannah Block, PhD

CONTACT

[email protected]

8128555390

About this study

Hand position can be estimated visually, from an image on the retina, and proprioceptively, from sensors in the joints, muscles, and skin. The brain is thought to weight and combine available sensory estimates to form an integrated multisensory estimate. Inherent in this process is the capacity to realign one or both sensory estimates when they become spatially mismatched, as when washing dishes with the hands immersed in water, which refracts light. It is generally assumed that if a person knows about the sensory mismatch somehow, the realignment will not occur. This assumption will be tested in two experiments by giving people this information in different ways. Expt. A: Conscious awareness of the mismatch will be presented in different ways, or absent. Expt. B: Movement error feedback will be presented in different ways, or absent.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Between the ages of 18-45 years old
  • Right-handed.
  • Covid has been found to have neurological effects in some people, but mostly the effects on sensorimotor control and neurophysiology are unknown. So we will only include individuals who report being free of Covid symptoms in week preceding testing.

Exclusion criteria

  • Past or present history of seizure, stroke, any brain or peripheral nerve disease, severe head trauma, or spinal cord surgery.
  • Learning or attention conditions such as ADHD.
  • Orthopedic or pain conditions, or a history of seriously injured bones, joints or muscles in either arm.
  • Lack of normal or corrected-to-normal vision.

Treatment and study plan

Explanatory diagram

Behavioral

Participant is told there will be a mismatch between their target finger and the visual indicator of target finger position. They will be shown a diagram explaining this.

Direct vision

Behavioral

Foamboard under mirror removed, making the mirror see-through and the hand directly visible. Mismatch between target hand and visual indicator will be directly visible.

Movement feedback, target hand

Behavioral

After the participant points at each target, a cursor indicating final pointing position will be displayed briefly. The visual indicator of the target hand will be displaced.

Movement feedback, pointing hand

Behavioral

After the participant points at each target, a cursor indicating final pointing position will be displayed briefly. The visual indicator of the target hand will not change, but the cursor indicating pointing hand position will change.

No movement feedback

Behavioral

The visual indicator of the target hand will be displaced, but there will be no cursor to indicate the pointing hand's position.

Attend to the targets

Behavioral

Participants will not be told anything about the visuo-proprioceptive mismatch. Instead, they will be asked simply to attend to the target positions.

Primary outcomes

  1. Realignment

    Time frame: 1 day

    Measured by comparing where the subject points on a touchscreen when indicating perceived position of visual and proprioceptive targets early vs. late in the behavioral task.

Secondary outcomes

  1. Visuo-proprioceptive weighting

    Time frame: 1 day

    The degree to which participant relies on vision vs. proprioception when both are available. Measured by comparing where the subject points on a touchscreen when indicating perceived position of visual vs. proprioceptive targets.

  2. Target estimation variance

    Time frame: 1 day.

    Variance with which participant estimate visual and proprioceptive target positions. Computed from where subjects point at targets on a touchscreen.

Study contacts

Contact information is provided by the study sponsor or research team.

Hannah J Block, PhD

CONTACT

[email protected]

8128555390

Sponsors and collaborators

Lead sponsor

Indiana University

Other

Collaborators

  • National Institute of Neurological Disorders and Stroke (NINDS)

Registry information

Important dates

Study start
2022
Primary completion
2027
Study completion
2027
First posted
May 16, 2022
Registry last updated
Aug 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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