Facilitating Safe Transition to Home for Preterm Infants - a National Database Study

Infants born preterm (i.e., before 37 completed weeks of pregnancy) often require additional care and are admitted to neonatal units. Depending on needs, preterm infants have varying lengths of hospital stay; most go home between 37 and 40 weeks' post-menstrual age. Before a preterm infant can go home, there must be a readiness for safe discharge. "Discharge readiness" typically requires a level of physiological maturity such that the infant can:

• Breathe without support: preterm babies often have breathing pauses (apnoea of prematurity); many require breathing support. With maturity, infants can breathe without support. Some may continue to need additional oxygen, and some go home on oxygen therapy.
• Maintain body temperature: initially preterm infants are nursed in incubators. As the ability to generate and preserve heat matures, infants may move into heated cots initially and then finally into regular cots with normal clothing and blankets.
• Feed adequately: preterm infants can take time to establish feeding. Initially potentially needing parenteral nutrition. Milk is slowly introduced via a gastric tube. As the ability to suck and swallow matures, infants learn to feed orally (on the breast or by bottle). To be discharged without additional support, infants need to be able to take milk requirements orally. Occasionally, where the service is available, infants can go home with partial nasogastric feeding.
• Gain weight: Most infants are considered ready if they weigh at least 1700-1800g and are consistently gaining weight.

In addition, families must be prepared to care for the infant independently (including keeping the baby warm, feeding, bathing, safe travel, and giving medicines) and be emotionally ready and confident.

Infants achieve maturity at variable pace and may become mature in some aspects but not all e.g., be able to breathe well, maintain temperature, and gain weight, but still be unable to take sufficient oral feeds. The final reason that keeps the infant in hospital is referred to as the "terminal or final discharge barrier". There is very little research to investigate the barriers to safe discharge and to find the most common "final discharge barrier" for preterm infants in the UK.

The study team will use data from the National Neonatal Research Database (NNRD) for all infants born at <37 weeks' gestational age and admitted to neonatal units in England and Wales from 2016-2022. The day of life and postmenstrual age each infant reaches each of the physiological barriers to discharge will be described, and the final 'barrier to discharge' to be reached will be identified. The study team will assess whether the final discharge barriers differ by gestational age and between neonatal units and summarise the number of days infants remain in the hospital after surpassing all physiological milestones. The study team will explore the characteristics of infants, mothers and neonatal units that are associated with extended hospital stays beyond physiological readiness for discharge.

Inclusion criteria

• Infants admitted to neonatal units that contribute data to the NNRD who are:
• Born at <37 completed weeks' gestational age
• Born from 01 January 2016 to 31 December 2022
• Admitted to neonatal care for >48 hours
• Discharged home alive