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NCT Number: NCT07314034

"Facially Driven Digital Full-Mouth Rehabilitation"

Participants with bite difficulties, smile dissatisfaction, and missing mandibular molars was rehabilitated using a fully digital, facially driven workflow. Integration of intraoral, facial, and CBCT data guided esthetic design, occlusion, and implant planning, resulting in precise alignment, functional occlusion, and esthetic restoration with veneers, zirconia crowns, TAD-assisted molar intrusion, and guided implants.

Recruiting

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Key information

Age range

20 year–45 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Faculty of Dentistry

Shibīn al Kawm, Menoufia, Egypt

Location status: Recruiting

Location contact

Mohammed A. El-Sawy

CONTACT

[email protected]

00201061314522

About this study

This Prospective study describes the comprehensive digital management of patients presenting with anterior open bite, smile dissatisfaction, and missing mandibular molars. A 3D virtual patient model was created by integrating intraoral scans, facial scans, and CBCT imaging, enabling prosthetically driven planning for esthetic and functional outcomes. Treatment involved conservative anterior rehabilitation with lithium disilicate veneers, full-coverage monolithic zirconia crowns, TAD-assisted intrusion of extruded molars, and guided implant placement for missing mandibular molars. The fully digital, facially guided workflow allowed precise restoration positioning, occlusal harmony, and predictable functional and esthetic results, demonstrating the utility of integrated digital planning in complex full-mouth rehabilitation.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 20-45 years with partial or complete edentulism requiring full-mouth rehabilitation.
  • Patients with bite dysfunction, malocclusion, or esthetic concerns suitable for digital workflow treatment.
  • Adequate bone volume for implant placement or candidates for TAD-assisted tooth movement.
  • Willingness to undergo treatment using a fully digital, facially guided workflow and comply with follow-up visits.
  • Ability to provide informed consent.

Exclusion criteria

  • Systemic conditions contraindicating implant or surgical procedures (e.g., uncontrolled diabetes, immunosuppression).
  • Active oral infections or untreated periodontal disease.
  • Heavy smokers (>10 cigarettes/day) or substance abuse.
  • History of head and neck radiation therapy or bisphosphonate use.
  • Pregnancy or breastfeeding.
  • Inability to comply with treatment or follow-up protocol.

Treatment and study plan

Facially Driven, Fully Digital Full-Mouth Rehabilitation with Guided Implant Placement, TAD-Assisted Molar Intrusion, and Restorative Crowns/Veneers

Device

Participants will receive full-mouth dental rehabilitation using advanced digital planning. Scans of the teeth, face, and jaw will guide treatment, which may include tooth movement with temporary devices, guided implant placement, and placement of custom veneers and crowns. This approach aims to restore bite function, improve smile esthetics, and ensure accurate, comfortable, and durable results.

Primary outcomes

  1. Implant Stability

    Time frame: 12 months post-treatment

    Clinical assessment: Absence of implant mobility assessed manually and using opposing instrument pressure.

    Radiographic assessment: Periapical radiographs using the paralleling technique to evaluate peri-implant bone levels.

    Success criteria: No progressive peri-implant radiolucency and marginal bone loss ≤ 1.5 mm during the first year, in accordance with Albrektsson et al. success criteria.

Study contacts

Contact information is provided by the study sponsor or research team.

Mohammed A. El-Sawy, PhD

CONTACT

[email protected]

00201061314522

Sponsors and collaborators

Lead sponsor

Menoufia University

Other

Collaborators

  • Mansoura University

Registry information

Official study title

Facially Driven Digital Workflow for Esthetic and Functional Full-mouth Rehabilitation

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Jan 2, 2026
Registry last updated
Jan 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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