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NCT Number: NCT07335146

Eye Imaging for the Study of Childhood Myopia

Myopia (nearsightedness) is increasing worldwide and is becoming a serious public health problem. Studies estimate that by 2050, if no action is taken, almost half of the world's population will be myopic. About 10% of people could develop severe myopia, which increases the risk of serious eye problems such as retinal detachment, damage to the macula, or glaucoma.

Children are particularly affected because myopia often worsens as they grow. Several treatments are now available to slow the progression of myopia in children, but these treatments are not equally effective for everyone. Some children respond better than others, and the reasons for these differences are not yet well understood. One possible explanation is that differences in eye anatomy may influence the effectiveness of a treatment. This suggests that myopia treatments may need to be tailored to each child. By studying the anatomy of the eye, researchers could improve and personalize myopia control strategies.

The study entitled "Eye imaging for the study of childhood myopia" aims to better understand the structure of children's eyes. The study will collect clinical data, including images of the eye taken with MRI and measurements of the eye obtained using standard eye examination devices. The data will then be analyzed using image-processing and statistical methods to allow a detailed study of children's eye anatomy.

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Key information

Conditions

Hyperopia and Myopia Eye Diseases Hyperopia Myopia Refractive Errors

Age range

6 year–12 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hôpital Fondation Adolphe de Rothschild

Paris, 75019, France

Location status: Recruiting

Location contact

Julien Savatovsky, Doctor

CONTACT

[email protected]

00331 48 03 69 30

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Spherical equivalent under cycloplegia greater -6.5 D and less than 2 D
  • Beneficiary of social security
  • Written consent from both holders of parental authority (or from one in case of exclusive parental authority)

Exclusion criteria

  • Declared neurological deficit, including history of epileptic pathology or sensory-motor coordination disorders, vestibular or cerebellar pathology (for example, balance disorders)
  • Current or progressive pathology of the eyes or their appendages that may affect vision, other than myopia (examples: glaucoma, retinitis pigmentosa…)
  • Declared aphakia or pseudophakia (intraocular implant)
  • Ocular motility problem such as strabismus or nystagmus
  • Contraindication to MRI (claustrophobia, implanted devices such as pacemaker, etc.)

Treatment and study plan

Ophtalmic measurements to estimate geometrical distances

Device

Patients will undergo routine ophthalmic examinations, such as ocular biometry to estimate axial length and corneal topography. Anatomical characteristics will then be derived from the geometric measurements obtained from each device. All measurements are non-invasive and non-ionizing. They all involve conventional ophthalmic devices that are widely used in clinical settings.

MRI

Device

Participants will undergo Magnetic Resonance Imaging (MRI) to image their eyes. A head antenna will be used. All measurements are non-invasive.

Ophtalmic measurements to measure wavefront aberrations

Device

Patients will undergo ophthalmic measurements to assess ocular wavefront aberrations. These measurements will be performed using commercially available devices that are widely accepted in routine clinical practice. All procedures are non-invasive and non-ionizing.

Primary outcomes

  1. Eye anatomy

    Time frame: From enrollment to 3 months after enrollment

    This set of data will enable an in-depth study of the eye anatomy: MRI will provide anatomical characteristics of the eyeball and its surrounding tissues such as the optical nerve. Ophtalmic measurements will provide anatomical characteristics of the eye's refractive system, such as corneal pachymetry, with optimal geometric resolution. Thus, MRI images and ophtalmic measurements will be combined to study the overall eye anatomy.

    Period: From inclusion up to 3 months after inclusion

Study contacts

Contact information is provided by the study sponsor or research team.

Julien Savatosky, Doctor

CONTACT

[email protected]

00331 48 03 69 30

Sponsors and collaborators

Lead sponsor

Essilor International

Industry

Registry information

Official study title

Modélisation de l'œil Myope Infantile Par IRM et OCT

Acronym: SELENA

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jan 13, 2026
Registry last updated
Mar 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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