Extracorporeal Filtration of Subarachnoid Hemorrhage Via Spinal Catheter

Inclusion criteria

• Age: 18 years or older
• Informed consent by the patient or his/her legally authorized representative
• Modified Fisher Grade 2, 3, or 4
• Hunt & Hess I-III
• First aneurysmal SAH that has been confirmed by Angio, CTA or MRA
• Patient is ≤ 48 hours post bleeding event
• World Federation of Neurosurgeons (WFNS) Grades I-IV and those Grade V patients who improve to Grade IV or less after ventriculostomy.

Exclusion criteria

• Patients with a SAH due to mycotic aneurysm or AV malformation
• Patients who present with an acute MI or unstable angina
• Patients with uncontrolled diabetes
• Patients who present with a creatinine > 2.0mg/dl
• Imaging demonstrates supratentorial mass lesions greater than 50 cc
• Imaging demonstrates more than 5 mm of mid-line-shift associated with infarction and or edema
• Effacement of the basilar cisterns (suprasellar, ambient, chiasmatic and quadrageminal)
• Vasospasm on admission as defined by angiographic evidence
• Patients with a coagulopathy that cannot be reversed per the professional discretion of the investigator
• Thrombocytopenia def. platelet count < 100,000
• Patients on low molecular weight heparin e.g., Lovenox
• Patients on Clopidogrel bisulfate (Plavix) or other chronic platelet inhibitors
• Patients with a documented history of cirrhosis
• Patients who will be managed with supportive care rather than intervention
• Obstructive hydrocephalus i.e., non-communicating
• Pregnancy
• History of posterior fusion hardware that would interfere with placement of the catheter
• Pre-existing Lumbar Drain
• Local skin infections or eruptions over the puncture site
• Signs of systemic infection/sepsis or pneumonia
• Lumbar puncture within 6 hours
• Concurrent participation in another study which is not observational or retrospective in nature without prior approval from the Sponsor