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Completed

NCT Number: NCT05158816

Extracorporal Membrane Oxygenation for Critically Ill Patients With COVID-19

Retrospective single center analyses of COVID-19 patients admitted to the ICU between 01/02/2020 and 31/07/2021.

Completed

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Jessa Hospital

Hasselt, Limburg, 3500, Belgium

About this study

All adults (>18 years) with acute hypoxaemic respiratory failure due to diagnosed COVID-19 pneumonia and admitted to ICU from 01/02/2020 until 31/07/2021 were included in the study. Following the World Health Organisation (WHO) protocol 19, laboratory confirmation of COVID-19 infection was defined as a positive result on polymerase chain reaction (PCR) assays of nasopharyngeal swab samples or bronchoalveolar lavage. Only laboratory-confirmed patients were included in the analysis.

Additional data collection

Additional collected parameters are listed below and are collected as a standard-of-care in our hospital:

  • Demographics: i.e age, gender, BMI
  • DNR code
  • Comorbidities: smoking, obesity, hypertension, diabetes, cardiovascular disease, respiratory disease, malignancies, renal failure (AKI), liver failure, gastrointestinal disease, neurological conditions, mental state, other
  • Symptoms at the time of admission to ICU: i.e fever, body temperature, dyspnoea, headache, diarrhea etc…
  • Laboratory results of all standard parameters measured
  • Treatment: antiviral agents, antibiotics, etc…
  • Complications: shock, heart failure, sepsis, stroke, etc…
  • Ventilation: method, PEEP, FiO2, P/F ratio ..

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All adult COVID-19 patients (>18 years) admitted to the ICU between 01/02/2020 and 31/07/2021 with a laboratory confirmation of COVID-19 infection with a positive result on polymerase chain reaction (PCR) assays of nasopharyngeal swab samples or bronchoalveolar lavage

Exclusion criteria

  • All adult patients admitted for other reasons to the ICU (no COVID-19 pneumonia)

Treatment and study plan

ECMO

Procedure

Patients undergoing extracorporeal membrane oxygenation

Primary outcomes

  1. Mortality

    Time frame: through study completion, an average of 1 year

    mortality of patients during their stay at the ICU

Secondary outcomes

  1. 3 Months Mortality

    Time frame: 3 months after admission to ICU

    Mortality of patients

  2. acute kidney injury

    Time frame: through study completion, an average of 1 year

    incidence of acute kidney injury

  3. continous renal replacement therapy

    Time frame: through study completion, an average of 1 year

    incidence of continous renal replacement therapy

  4. Length of stay in hospital

    Time frame: through study completion, an average of 1 year

    Length of stay in hospital

  5. Length of stay in ICU

    Time frame: during ICU stay

    Length of stay in ICU

Other outcomes

  1. Complications

    Time frame: through study completion, an average of 1 year

    description of possible complications after ECMO

Sponsors and collaborators

Lead sponsor

Jessa Hospital

Other

Registry information

Official study title

Extracorporal Membrane Oxygenation for Critically Ill Patients With COVID-19: a Single Centre Analysis

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Dec 15, 2021
Registry last updated
Dec 21, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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