Extracellular Vesicles for Rejection Monitoring in Cardiac Transplantation

Inclusion criteria

• Subject is either on the heart transplant waiting list or is still hospitalised following HTx surgery.
• Age of subject is ≥ 18 years.
• Subject is female or male.
• Capacity to consent.
• Signed written informed consent.
• For female subjects:

• Confirmed post-menopausal state, defined as amenorrhea for at least 12 months, or
• If being of childbearing potential: Negative highly sensitive urine or serum pregnancy test before inclusion.

Exclusion criteria

• Concurrent multiple solid organ or tissue transplants.
• Prior history of any organ or cellular transplantation.
• Subject suffers from an addiction or from a disease that prevents the subject from recognising nature, scope, and consequences of the study.
• Subject shows an inability to comply with all the study procedures and follow-up visits.
• Subject is legally detained in an official institution.
• Subjects who are unwilling to consent to saving and propagation of pseudonymised medical data for study reasons.
• Subject is financially dependent on the investigators or the study site.