Extracellular Vesicles as Biomarkers for Chronic Renal Failure

The recent discovery of extracellular vesicles (EV) as a mechanism of intercellular communication has made it possible to develop a new field of health research and could bring new information on the pathological mechanisms of renal diseases. Definition of physiologic and pathologic values of urinary extracellular vesicles (EVu) between healthy subjects and chronic kidney diseases (CKD) patients could be a new tool for follow up of renal diseases. EV are found in all biological fluids including urine, that's why they are increasingly analyzed in renal pathologies. The main objective of this study is to determine the physiological values and the pathological thresholds of EVu.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Chronic Renal Failure Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Kidney Failure, Chronic Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urinary Extracellular Vesicle Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU Amiens

Amiens, 80480, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

subject > 18 years old
healthy subjects : no medical history, in particular cardiovascular, without drug treatment, without proteinuria, normal BMI
CRF patients : eGFR estimated according to the MRDR formula less than 89 mL/min/1,73m²

Exclusion criteria

patients under dialysis protocols
renal transplant patients

Treatment and study plan

urinary extracellular vesicle concentration

Diagnostic Test

urinary extracellular vesicle concentration will be determined in urine samples from CRF and healthy patients

Blood sample

Diagnostic Test

blood sample in order to determine creatin level

Primary outcomes

variation of urinary extracellular vesicle concentration between both groups

Time frame: one day

variation of urinary extracellular vesicle concentration between both groups : healthy and CRF patients Urinary extracellular vesicle concentrations will be measured as number of extracellular vesicles per mL of urine

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Registry information

Acronym: VE-IRC

Important dates

Study start: 2021
Primary completion: 2023
Study completion: 2023
First posted: Jan 8, 2021
Registry last updated: Sep 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed