Clearance with the left side of the SMV as the medial boundary
ProcedureUndergo radical resection for right colon cancer with the left side of the SMV as the medial boundary
Not Yet Recruiting
NCT Number: NCT06986538
Extent of Lymph Node Dissection for Advanced Right-Sided Colon Cance
This is a prospective multicenter randomized controlled clinical study to explore the extent of lymph node dissection in progressive right hemicolon cancer and to elucidate the pattern of lymphatic drainage in the right hemicolon.
Not Yet Recruiting
Trial opening soon.
Get NotifiedKey information
Age range
18 year–75 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
Cancer Hospital, Chinese Academyof Medical Sciences, Beijing, Beijing Municipality, China
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Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Age: 18-75 years
- Preoperative pathologic confirmation of adenocarcinoma
- Tumor located in the region from the ileocecal valve to the right one-third of the transverse colon
- American Society of Anesthesiologists (ASA) physical status classification I to III
- Patients who have not received preoperative radiotherapy, chemotherapy, or immunotherapy
- Preoperative imaging staging cT4N0M0 or cT3-4N+M0
- Willing to participate in the study and sign the informed consent form
Exclusion criteria
- Past medical history of malignant tumor
- Patients with multiple primary tumors
- Patients with a history of inflammatory bowel disease or familial adenomatous polyposis
- Patients with distant metastasis
- Pregnant or breastfeeding women
- History of other previous major abdominal surgery
- Patients requiring emergency surgery (including tumor perforation, obstruction, hemorrhage, etc.)
- Those with other clinical and laboratory conditions deemed by the investigator to be inappropriate for participation in the trial
Treatment and study plan
Clearance with the left side of the SMA as the medial boundary
ProcedureUndergo radical resection for right colon cancer with the left side of the SMA as the medial boundary
Primary outcomes
-
Disease-Free Survival
Time frame: The third postoperative year
It is defined as the proportion of patients from the start of randomization to the end of the third year without any of the following events: disease progression, local recurrence, distant metastasis, second primary colorectal cancer, or death from any cause.
Secondary outcomes
-
overall survival
Time frame: The third postoperative year
The time from randomization to death from any cause.
Study contacts
Contact information is provided by the study sponsor or research team.
Dechang Diao
CONTACT
Jiaqi Ren
CONTACT
Sponsors and collaborators
Lead sponsor
Sixth Affiliated Hospital, Sun Yat-sen University
Other
Registry information
Official study title
A Multicenter Randomized Controlled Study of the Extent of Lymph Node Dissection for Advanced Right-sided Colon Cancer
Acronym: MARCH
Important dates
- Study start
- 2025
- Primary completion
- 2029
- Study completion
- 2029
- First posted
- May 23, 2025
- Registry last updated
- May 23, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.