Extended Work Schedules, Sleep Loss and Health

This study aims to determine whether abnormal bodily rhythms contribute to elevate the risk of diabetes, independently of the amount of sleep loss.

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Key information

Conditions

Sleep Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

21 year–39 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The University of Chicago

Chicago, Illinois, 60637, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

normal healthy men and women between the ages of 21 years and 39 years (inclusive) with normal weight (i.e., body mass index under 28 kg/m2 in men, 27 kg/m2 in women)
normal findings on clinical examination, normal results on routine laboratory tests, normal EKG, normal glucose tolerance test, negative pregnancy test for women
no personal history of psychiatric or endocrine illness
no personal history of sleep disorder, usual total sleep time of at least 7 hours
only female volunteers with normal ovulatory cycles will be included

Exclusion criteria

subjects with irregular life habits (shiftworkers and subjects having traveled across time zones less than one month prior to the beginning of the baseline study)
subjects taking any medication (including hormonal contraceptive therapy), and smokers are excluded
subjects with significant sleep apnea (apnea index above 10) or significant arousal-associated periodic leg movements are excluded

Treatment and study plan

Fixed restricted bedtimes

Behavioral

Sleep restricted to 5 hours per night for 8 nights

Sleep restriction with circadian misalignment

Behavioral

Sleep restricted to 5 h per day for 8 days, alternating night sleep and day sleep

Sponsors and collaborators

Lead sponsor

University of Chicago

Other

Registry information

Official study title

Extended Work Schedules and Health: Role of Sleep Loss

Acronym: EW and EWD

Important dates

Study start: 2003
Primary completion: 2007
Study completion: 2009
First posted: Oct 5, 2009
Registry last updated: Oct 3, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed