Expression of Tim-3 on Neutrophils in Ankylosing Spondylitis

1. To investigate the expression of Tim-3 on neutrophils in ankylosing spondylitis patients and its correlation with disease activity and inflammatory markers. 2. Association of Tim-3 with sacroiliac MRI findings and the hip inflammatory MRI scoring system (HIMRISS) .

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Key information

Conditions

Ankylosing Spondylitis AS Ankylosis Arthritis Axial Spondyloarthritis Bone Diseases Joint Diseases Musculoskeletal Diseases Spinal Diseases Spondylarthritis Spondylarthropathies Spondylitis Spondylitis, Ankylosing Tim3

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Assiut university

Asyut, University, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Adult patients (>18 years) diagnosed as AS according to 2009 ASAS -Classification criteria (8) Exclusion Criteria:-Age below 18 years old. Patients with other autoimmune diseases. infection (cause increase in inflammatory makers) Any patient with ferromagnetic implants or cardiac pacemaker pregnancy Uncontrolled Hypertension renal failure Chronic liver disease Malignancy Diabetes Mellitus

Treatment and study plan

Primary outcomes

To investigate the expression of Tim-3 on neutrophils in ankylosing spondylitis patients

Time frame: through study completion, an average of 1 year

investigate the expression of Tim-3 on neutrophils in ankylosing spondylitis patients and its correlation with disease activity and inflammatory markers

Study contacts

Contact information is provided by the study sponsor or research team.

Eman Safwat, MD

CONTACT

[email protected]

01014116158

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Expression of T Cell Immunoglobulin and Mucin-domain Containing Molecule 3 (Tim-3) on Neutrophils as an Indicator to Assess Disease Activity in Ankylosing Spondylitis Patients

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2029
First posted: Feb 3, 2026
Registry last updated: Feb 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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