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Completed

NCT Number: NCT05196425

Expression of PARP-1 in Multiple Sclerosis Patients

This study will explore the expression of PARP-1 in optic neuritis of multiple sclerosis patients.

The data will be collected from Sohag University hospital in the period from the start of August 2021 to the end of December 2021.

The study protocol will be approved by the Scientific Research Ethical Committee, Faculty of Medicine, Sohag University.

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Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Immune System Diseases Nervous System Diseases

Age range

20 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Elshimaa A.Mateen

Sohag, 82511, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with multiple sclerosis with or without optic neuritis Multiple sclerosis will be diagnosed according to the McDonald criteria

Exclusion criteria

  • • Isolated optic neuritis.

Treatment and study plan

Blood Sampling

Genetic

Blood sample for detection of PARP-1 gene and correlate to changes of the optic disc, RNFL and GCC layers of the retina of MS patients

Primary outcomes

  1. measure PARP-1 mRNA

    Time frame: 2 weeks

    measure PARP-1 mRNA

Secondary outcomes

  1. Optic nerve, RNFL and GCC layer affection by MS

    Time frame: 2 weeks

    Optic nerve Retinal nerve fibre layer (RNFL) in um

    ) and Ganglion cell complex (GCC) layer affection in um by MS in correlation to PARP-1 mRNA

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Expression of PARP-1 in Optic Neuritis of Multiple Sclerosis Patients

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Jan 19, 2022
Registry last updated
May 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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