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OpenTrials
Completed

NCT Number: NCT01976884

Expression and the Clinical Significance of Neutrophil PD-L1 During Sepsis

Immunosuppression is the leading cause of death in septic patients. Neutrophils are classical components of innate immunology, but recent studies showed that neutrophils might display antigen presenting function and inhibit lymphocyte proliferation by expressing programmed cell death 1 ligand 1 (PD-L1). Whether neutrophils express PD-L1 and its role in immunosuppression during sepsis remain unclear.

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Key information

Conditions

Sepsis Immunosuppression Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with severe sepsis
  • patients with sepsis after PCNL for infectious kidney stone
  • patients with pancreatic cancer
  • healthy volunteers

Exclusion criteria

  • patients with immunodeficient diseases
  • patients who accept glucocorticoid or immunosuppressant
  • patients with an age older than 18 years
  • patients providing the informed consent

Treatment and study plan

Primary outcomes

  1. PD-L1 level on neutrophils

    Time frame: within 24h after recruitment

    PD-L1 level on neutrophils was compared between different populations.

Secondary outcomes

  1. 28-day mortality

    Time frame: 28 days after diagnosis of sepsis

Sponsors and collaborators

Lead sponsor

Changhai Hospital

Other

Registry information

Important dates

Study start
2011
Primary completion
2013
Study completion
2013
First posted
Nov 6, 2013
Registry last updated
Nov 6, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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