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NCT Number: NCT07287267

Exploring the Relationship Between Range of Motion in Knee Rehabilitation Exercises and Pain in Patellofemoral Pain Syndrome

This study aims to investigate the relationship between knee joint range of motion and pain in patients with patellofemoral pain syndrome (PFPS). In a cross-sectional observational design, PFPS patients will perform trials involving progressively increased knee joint range of motion in three closed-chain exercises: squat, single-leg squat, and split squat. During each trial, participants will report pain levels on a 0-10 Visual Analog Scale (VAS) until either (1) achieving full depth in the respective exercise or (2) reaching a pain level of >5 on the VAS.

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Key information

Conditions

Patello Femoral Syndrome Joint Diseases Musculoskeletal Diseases Patellofemoral Pain Syndrome

Age range

15 year–35 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients diagnosed with PFP in only one knee by a licensed healthcare professional.
  • Aged 15-35 years.
  • A physical activity level of 3/10 or higher on the Tegner Activity Scale before the injury.

Exclusion criteria

  • Any prior injury or condition with residual symptoms that may affect the results.
  • Current injury or condition affecting the performance of the test.
  • Resting pain greater than 0-1/10 on the Numeric Pain Rating Scale (NRS) and pain greater than 1-2/10 during light daily activities such as walking, sitting, standing, or climbing stairs.

Treatment and study plan

Exercise

Other

Exercise with progressively increased range of motion.

Primary outcomes

  1. Pain (VAS)

    Time frame: Day 1 (Cross sectional single session. Outcomes will be collected during one single session for each participant.)

    Pain measured 0-10 visual analog scale (VAS) reported during each trial of progressively increased range of motion during a single session.

  2. Range of motion

    Time frame: Day 1 (Cross sectional single session. Outcomes will be collected during one single session for each participant.)

    Degrees of knee flexion measured during each trial in one single session.

Secondary outcomes

  1. Force

    Time frame: Day 1 (Cross sectional single session. Outcomes will be collected during one single session for each participant.)

    Force (N) (peak value) reported during the different trials in one session. Measured by force plates.

  2. Tegner Activity Scale (TAS)

    Time frame: Baseline (Administered at the beginning of the study)

    The Tegner Activity Scale (TAS) will be used to assess the physical activity levels of the participants. Scale from 1-10 where 10 is highest possible physical activity and 1 is sedentary.

Sponsors and collaborators

Lead sponsor

Ted Gunhamn

Other

Registry information

Important dates

Study start
2024
Primary completion
2025
Study completion
2026
First posted
Dec 17, 2025
Registry last updated
Dec 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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