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NCT Number: NCT06692309

Exploring the Predictive Value of Electroencephalography Features in Perioperative Neurocognitive Disorders Following Cardiovascular Surgery

To explore the predictive value of Electroencephalography features in Perioperative Neurocognitive Disorders in patients undergoing cardiovascular surgery under general anesthesia

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Key information

Conditions

Cardiovascular Surgery Perioperative Neurocognitive Disorders

Age range

60 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Beijing Chao Yang Hospital

Beijing, Beijing Municipality, 100020, China

Location status: Recruiting

Location contact

Changwei Wei

CONTACT

[email protected]

13810678936 ext. +86

About this study

Data was acquired on the ward using a 10-20 system with a standard 32-channel EEG cap and an EEG instrument (BP Company, Gilching, Germany). Patients were tested using cognitive assessment scales before and after surgery.

Cognitive levels were assessed 1 day before surgery and 1 week after surgery (7±2 days) using the Montreal Cognitive Assessment (MoCA) . Patients were followed up one month (30±2 days) after surgery using the Telephone version of the Montreal Cognitive Assessment Scale (T-MoCA).

Preoperative and postoperative electroencephalography brain network-related indexes (such as cluster coefficient, small world index, etc.) in patients with PND will be included in the analysis.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Written informed consent
  • undergoing coronary artery bypass surgery or valve replacement surgery under general anaesthesia
  • ASA grade: II-IV
  • older than 60 years
  • Able to complete cognitive function tests

Exclusion criteria

  • history of severe neurological diseases and psychiatric diseases
  • history of drug abuse
  • severe hearing or vision impairment
  • preoperative delirium
  • serious adverse reactions such as cardiac arrest and cardiopulmonary resuscitation during surgery
  • patients undergoing secondary surgery in a short period
  • participation in concurrent clinical trials

Treatment and study plan

cardiovascular surgery

Procedure

Heart bypass surgery; Heart valve replacement surgery

Primary outcomes

  1. The predictive value of preoperative Electroencephalography features in patients with postoperative cognitive dysfunction following cardiovascular surgery

    Time frame: 2025.08

    Data was acquired on the ward using a 10-20 system with a standard 32-channel EEG cap and an EEG instrument (BP Company, Gilching, Germany). Patients were tested using cognitive assessment scales before and after surgery.

    Cognitive levels were assessed 1 day before surgery and 1 week after surgery (7±2 days) using The Montreal Cognitive Assessment (MoCA) . Patients were followed up one month (30±2 days) after surgery using the Telephone version of the Montreal Cognitive Assessment Scale (T-MoCA).

Secondary outcomes

  1. The predictive value of preoperative Electroencephalography features in patients with postoperative delirium following cardiovascular surgery

    Time frame: 2025.08

    Postoperative delirium was assessed using the confusion assessment method or the confusion assessment method for the intensive care unit (CAM/CAM-ICU) .

  2. Electroencephalography features in patients with postoperative delirium

    Time frame: 2025.08

    Electroencephalography was collected in delirium patients one week(7±2 days) after surgery. Postoperative delirium was assessed using the confusion assessment method or the confusion assessment method for the intensive care unit (CAM/CAM-ICU) .

    Preoperative and postoperative electroencephalography brain network-related indexes (such as cluster coefficient, small world index, etc.) in patients with postoperative delirium will be included in the analysis.

Study contacts

Contact information is provided by the study sponsor or research team.

Changwei Wei, doctor

CONTACT

[email protected]

13810678936 ext. +86

Sponsors and collaborators

Lead sponsor

Beijing Chao Yang Hospital

Other

Registry information

Official study title

To Explore the Predictive Value of Electroencephalography Features in Perioperative Neurocognitive Disorders in Patients Undergoing Cardiovascular Surgery Under General Anaesthesia: a Single-centre Prospective Observational Study

Important dates

Study start
2023
Primary completion
2025
Study completion
2026
First posted
Nov 18, 2024
Registry last updated
May 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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