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NCT Number: NCT07505134

Exploring the Influence of Glucagon-like Peptide -1 (GLP-1) Medications on Food Cravings, Food Selection, and Food Intake Following Exposure to Food Advertisements

The purpose of this randomized control trial is to compare how food cravings, food selection, and food consumption change in response to frequent food advertisements compared to non-food advertisements in adults taking GLP-1 (weight loss) medications. The primary question we aim to answer is: do GLP-1 medications reduce an individual's vulnerability to external triggers that drive food cravings and consumption?

Participants will:

* report daily food consumption for a total of 10 days, * receive eight daily prompts to view food or non-food related advertisements, and respond to a short 9-question survey for 7 days, * answer several questionnaires, * and complete two in-person visits to complete a virtual reality food selection task.

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Key information

Conditions

GLP - 1

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults (18+) with overweight or obesity (BMI >25 kg/m2)
  • On an injectable form of tirzepatide GLP-1 medication at a minimum dose of 7.5 mg, taking it as prescribed by their doctor
  • Not currently taking an incretin-based medication at baseline other than the GLP-1 medication
  • Fluent in English

Exclusion criteria

  • Do not have consistent access to a smart phone that can access the study software
  • Diagnosed with cognitive or physical disability or epilepsy
  • Adults taking a compound GLP-1

Treatment and study plan

Food advertisements

Behavioral

Videos and images of food and beverage advertisements from popular brands and/or restaurants

Tech advertisements

Behavioral

Video and photo advertisements of popular tech tools

Primary outcomes

  1. Mean food cue reactivity scores in the afternoon

    Time frame: 7-day period of all afternoon survey responses

    Average scores of craving levels for each group following afternoon advertisement viewing sessions

  2. Mean food cue reactivity scores in the morning

    Time frame: 7-day period of all morning survey responses

    Average scores of craving levels for each group following morning advertisement viewing sessions

  3. Mean food cue reactivity scores in the evening

    Time frame: 7-day period of all evening survey responses

    Average scores of craving levels for each group following evening advertisement viewing sessions

  4. Mean food cue reactivity scores overall

    Time frame: 7-day period of all survey responses

    Average scores of craving levels for each group over all viewing sessions

  5. Energy density of consumed foods

    Time frame: 7 days

    The energy density profile of foods consumed each day

Secondary outcomes

  1. Change from baseline in energy density of foods selected in the virtual buffet

    Time frame: Baseline and 7 days

  2. Changes in food noise since being on medication questionnaire

    Time frame: Baseline

    Questionnaire assessing various aspects of food noise at present compared to before the medication

  3. Changes in reasons for purchasing foods questionnaire

    Time frame: Baseline

    A questionnaire that assesses how five factors impact purchasing choices, and how the main factors have changed between prior to starting the medication and after.

  4. Individual Food Cue Responsiveness--Trait

    Time frame: Baseline

  5. Change in brand familiarity, liking, and/or craving

    Time frame: Baseline and 7 days

    A questionnaire that measures the familiarity, liking, and craving of each brand the participant will be exposed to (baseline) or has been exposed to (after intervention).

Sponsors and collaborators

Lead sponsor

Penn State University

Other

Collaborators

  • Penn State Health

Registry information

Official study title

Exploring the Influence of GLP-1 Medications on External Food Cue Reactivity and Resultant Food Choice and Intake

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 1, 2026
Registry last updated
May 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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