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Completed

NCT Number: NCT00696033

Exploring the Effects of Diazepam and Lorazepam

Aims :

* exploring lorazepam (0.038 mg/kg) effects, after a single oral intake, in healthy volunteers, on the neural correlates of encoding and retrieval of information during a word-stem completion task (implicit memory), using fMRI * comparing lorazepam effects to diazepam (0.3 mg/kg)effects * exploring benzodiazepines effects, after a single oral intake, on the neural correlates of successful encoding of information within explicit memory using fMRI

Hypothesis :

* both diazepam and lorazepam will impair explicit memory performance, but lorazepam only will impair perceptual priming * lorazepam and diazepam will modify the normal correlates of information encoding within explicit memory * lorazepam only will alter the neural correlates of perceptual priming

Completed

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Key information

Conditions

Healthy Subjects

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Centre d'investigation clinique, hôpital civil, Strasbourg, France

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Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy subjects between 18 and 30 years
  • Students in medicine, dentistry or pharmacy
  • French as a mother language

Exclusion criteria

  • Medical condition influencing brain function (neurological or psychiatric)
  • Asthma
  • General anesthesia in the 3 last months
  • Drug addiction (DSM IV criteria)
  • Regular medical treatment (except contraceptive pill)
  • Significant impairment observed during a medical examination including ECG
  • Intake of any psychotropic drug that can have a effect during testing
  • IQ (Wechsler) < 100
  • FMRI contra-indication (implantable magnetic material, claustrophobia)
  • Known allergy to benzodiazepine or lactose
  • > 10 cigarettes/day
  • Pregnant or breast-feeding woman
  • No health insurance
  • Subjects who do not complete the entire study

Treatment and study plan

Diazepam

Drug

Diazépam drug (0,3 mg/kg) on a single oral intake

Lorazepam

Drug

Lorazépam drug (0,038 mg/kg) on a single oral intake

Placebo

Drug

lorazépam placebo or Diazépam placebo

Primary outcomes

  1. Exploring lorazepam (0.038 mg/kg) effects, after a single oral intake, in healthy volunteers, on the neural correlates of encoding and retrieval of information during a word-stem completion task (implicit memory), using fMRI

    Time frame: After a single oral intake

Secondary outcomes

  1. Comparing lorazepam effects to diazepam (0.3 mg/kg)effects

    Time frame: After a single oral intake

  2. Exploring benzodiazepines effects, after a single oral intake, on the neural correlates of successful encoding of information within explicit memory using fMRI

    Time frame: After single oral intake

Sponsors and collaborators

Lead sponsor

University Hospital, Strasbourg, France

Other

Registry information

Official study title

Exploring the Effects of Diazepam and Lorazepam on the Neural Correlates of Perceptual Priming and Explicit Memory in Healthy Volunteers

Acronym: ibid

Important dates

Study start
2007
Primary completion
2008
Study completion
2008
First posted
Jun 12, 2008
Registry last updated
Sep 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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