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NCT Number: NCT05716737

Exploring Radiotherapy of Temporomandibular Joint Arthritis

With this pilot study, the acute side effects and potential pain relieve after radiotherapy (RT) of the temporomandibular joint (TMJ) are prospectively recorded.

For this purpose, the symptoms of the jaw joint arthrosis/arthritis are recorded using a symptom-oriented questionnaire and the numeric rating scale for pain assessment.

Furthermore, it is examined whether the irradiation is feasible.

Recruiting

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Key information

Conditions

Arthritis of Temporomandibular Joint

Age range

50 year–100 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • TMJ arthritis
  • diagnosed by a surgeon for oral and maxillofacial surgery or a dentist

Exclusion criteria

  • Previous irradiation in the TMJ area
  • Age below 50 years

Treatment and study plan

Irradiation

Radiation

3 Gy in 6 fractions to the TMJ, every other day, LINAC based

Primary outcomes

  1. therapeutic effect

    Time frame: Before, directly after treatment and after 3, 6 9 and 12 months

    Pain, Numeric rating scale (0-10, 0=no pain, 10=maximum pain)

Secondary outcomes

  1. Other temporomandibular joint conditions

    Time frame: Before, directly after treatment and after 3, 6 9 and 12 months

    Questionnaire (covering the condition of the temporomandibular joint and masticatory muscles, Version: 12.03.2018 (FB II) of the University of Leipzig)

Study contacts

Contact information is provided by the study sponsor or research team.

Cora Waldstein, MD

CONTACT

[email protected]

004314040026920

Matthias Moll, MD

CONTACT

[email protected]

004314040026920

Sponsors and collaborators

Lead sponsor

Medical University of Vienna

Other

Registry information

Important dates

Study start
2023
Primary completion
2024
Study completion
2027
First posted
Feb 8, 2023
Registry last updated
Sep 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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