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NCT Number: NCT07460609

Exploring Blood Flow Restriction as an Accessible Fitness Solution for Healthy Aging in Seniors

As people age, it can become harder to stay active and independent, especially when dealing with fatigue, joint pain, or other health problems. Heavy weightlifting and high-intensity exercise are effective but may not be comfortable or realistic for many older adults. This study is looking at a gentler type of exercise called blood flow restriction (BFR) training, which uses light weights and slow walking combined with special bands around the arms and legs to gently reduce blood flow during exercise. This method has been shown to help improve strength and fitness using much lighter loads, which may make it a safer and more accessible option for older adults.

In this study, adults age 60 and older will be randomly assign into one of two groups: an exercise group or a health education group. The exercise group will take part in a six-week BFR program that includes supervised light resistance exercises and short walking sessions each week. The health education group will attend three educational sessions over six weeks that focus on healthy aging and ways to manage health and stay active. After the first six weeks, participants will have the chance to switch and take part in the other program, so everyone eventually receives both exercise and education.

Before and after each program, participants will complete simple tests of strength, walking ability, and physical function, along with measurements of heart and blood vessel health, body composition, and blood markers related to aging and overall health. They will also fill out questionnaires about their quality of life, physical activity, and how they feel about their health and aging. The goal of this study is to find out whether BFR exercise and health education can support healthy aging, improve physical function, and help older adults feel more positive and confident about their health. What the study investigators learn may help create better, more accessible programs in the community to keep older adults stronger, healthier, and more independent.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Age range

60 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Marrs McLean Gym

Waco, Texas, 76706, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Community-dwelling adults aged 60 years or older,
  • Able to walk independently ,
  • Willing to provide informed consent and participate in exercise and/or health education sessions.

Exclusion criteria

  • Adults with uncontrolled disease (unstable or recent angina, heart failure class III-IV,
  • Myocardial infarction within 6 months,
  • Uncontrolled hypertension,
  • Uncontrolled diabetes,
  • Recent deep vain thrombosis,
  • Uncontrolled renal disease,
  • Those with severe orthopedic or neuromuscular condition that limit safe exercise or walking.

Treatment and study plan

Blood Flow Restriction Training Exercise

Behavioral

Participants will complete a six-week blood flow restriction exercise program consisting of low-load resistance training and short BFR walking sessions performed with standardized cuff pressures under supervision and at home to improve strength and functional capacity.

Health Education

Behavioral

Participants will attend a three health education lectures within six weeks on healthy aging, disease prevention, and lifestyle strategies while maintaining their usual daily activities.

Primary outcomes

  1. Functional Exercise Capacity

    Time frame: baseline and 6 weeks.

    Measured by the distance in meters covered during a 6-minute walk.

  2. Grip Strength

    Time frame: Baseline and 6 weeks.

    Measured with a hand grip dynamometry in kilograms

  3. Lower Body Strength and Endurance

    Time frame: Baseline and 6 weeks

    Measured with a sit-to-stand test, seconds to complete 5 repetitions of sitting and standing from a chair.

  4. Body Composition

    Time frame: Baseline and 6 weeks

    Adiposity will be measured by Dual energy x-ray absorptiometry as percent of body fat

  5. Endothelial Function

    Time frame: Baseline and 6 weeks

    Measured via brachial artery flow mediated dilation. Percent FMD

  6. Biomarker of Genetic Aging

    Time frame: Baseline and 6 weeks

    Klotho a marker of aging will be quantified through blood samples analysis. Measured with Enzyme-Linked Immunosorbent Assay.

  7. Metabolic Health

    Time frame: Baseline and 6 weeks

    Cholestech LDX analyzer will measure levels of cholesterol HDL mg/dL from a finger prick sample.

  8. Metabolic Health

    Time frame: baseline and 6 weeks.

    Cholestech LDX analyzer will measure levels of cholesterol LDL mg/dL from a finger prick sample.

  9. Metabolic Health

    Time frame: Baseline and 6 weeks

    Cholestech LDX analyzer will measure levels of glucose mg/dL from a finger prick sample.

Secondary outcomes

  1. Body Mass Index (BMI)

    Time frame: Baseline and 6 week

    BMI will be determined using weight in kilogram and height in meters squared. kg/m2

  2. Blood Pressure

    Time frame: Baseline and 6 weeks.

    Blood pressure will be measured using an automated oscillometric sphygmomanometer to determine systolic and diastolic blood pressure in mmHg.

Other outcomes

  1. Height

    Time frame: Baseline and 6 weeks

    Height will be measured in meters and will be used determine BMI kg/m2

  2. Weight

    Time frame: Baseline and 6 weeks

    Weight will be measure in kilograms with a floor scale, and will be used to determine BMI kg/m2

Sponsors and collaborators

Lead sponsor

Baylor University

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Mar 10, 2026
Registry last updated
Mar 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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