Exploratory Study to Determine Tissue Alterations of Advanced Hepatocellular Carcinoma Induced by Electromagnetic Waves of Low Energy Amplitude Modulated to Specific Frequencies During Imaging Study by MRI

Inclusion criteria

All individuals selected for these studies should be in accordance with the following inclusion criteria:

• Patients must have a diagnosis of HCC.
• Presence of the primary or metastatic tumor at the time of the procedure, at least one (1) measurable lesion by RECIST criteria modified located in the hepatic parenchyma and size> 2 cm.
• Patients with AFP> 400 ng / ml and image feature not need histopathological confirmation. But in patients with active B virus serology, the value of AFP should be greater than 4000 ng / ml. The remaining patients should be histological confirmation of HCC.
• Patients may be in observation or presence of systemic or intra-hepatic treatment.
• Minimum age 18 years.
• be subjected to MRI study without need for sedation.

Exclusion criteria

• Individuals selected for this study will be excluded if they are in accordance with the following exclusion criteria:

• can not suspend anti-hypertensive drugs or beta blockers for at least 48 hours or be pacemaker carriers or other implantable device.
• Any restriction known to carry out study of magnetic resonance imaging.
• menstrual delay, pregnant or breastfeeding.
• Presence of metal artifacts or implants that can alter the reading of the magnetic signal or heat or move during the MRI procedure.
• Prior allergic Event Knowledge gadolinium or manganese chloride solution.