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Completed

NCT Number: NCT03186820

Exploratory Study of the Interest of MRI Susceptibility Weighted Imaging for the Pre-operative Assessment of Pelvic Endometriosis Extent

Knowledge of the precise location of endometriosis is essential for a successful surgical treatment. MRI Susceptibility-Weighted Imaging (SWI-MRI) yields high sensitivity for blood by-products detection. Since endometriosis lesions are haemorrhagic, and therefore rich in blood by-products such as hemosiderin, SWI-MRI could be useful in the pre-operative assessment of endometriosis, especially in superficial peritoneal lesion detection. The purpose of our study is to evaluate the performance of SWI-MRI for the preoperative work-up of endometriosis

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Key information

Conditions

Endometriosis Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Urogenital Diseases

Age range

18 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

CHU de Bordeaux

Bordeaux, 33076, France

About this study

Pelvic endometriosis is a cause of pelvic pain, dysmenorrhea, urinary symptoms and infertility. MRI is considered as the best imaging technique to detect and to predict the extent of the disease. Susceptibility Weighted Imaging is routinely performed to identify haemorrhagic lesions in brain MRI protocols and has proven to be a sensitive technique to detect blood by-products. A pelvic MRI protocol including SWI will be performed in all women addressed for diagnostic assessment or pre-operative work-up of endometriosis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult woman (over 18yrs old) addressed for diagnostic assessment or pre-operative work-up of endometriosis;
  • Informed signed consent
  • Affiliated or beneficiary of a social security system

Exclusion criteria

  • Patient <18yrs old
  • Pregnant or nursing woman
  • Patient under legal protection
  • Contraindication to MRI

Treatment and study plan

Susceptibility Weighted Imaging as 3D SWAN sequence

Other

Susceptibility Weighted Imaging as 3D SWAN sequence

Primary outcomes

  1. Interest of MRI Susceptibility Weighted Imaging

    Time frame: Baseline (MRI) and day of surgery

    The diagnostic use of SWI-MRI will be assessed through:

    • the number of endometriotic locations, which are both identified with SWI-MRI and confirmed by surgery.
    • the sensitivity, specificity, and predictive values of MRI.
    • signal intensities of each endometriotic location found in surgery on T1 weighted sequence (presence of a high signal intensity) and SWI (presence of a low signal intensity)

Secondary outcomes

  1. Deep forms of endometriosis

    Time frame: Baseline (MRI) and day of surgery

    MRI findings will be compared to surgical findings

  2. Superficial forms of endometriosis

    Time frame: Baseline (MRI) and day of surgery

    MRI findings will be compared to surgical findings

Sponsors and collaborators

Lead sponsor

University Hospital, Bordeaux

Other

Registry information

Acronym: EndoSWI

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Jun 14, 2017
Registry last updated
Jun 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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