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Completed

NCT Number: NCT05650853

Exploration of eJaculatory Anatomy Concept Study (EJAC Study)

Ejaculatory dysfunctions (ED) are an important cause of postoperative dissatisfaction, which lead to a decrease in the intensity of orgasms in 50% of patients. ED is a cause for concern for almost a third of patients who need surgery. Surgical techniques have been developed to limit the occurrence of postoperative ED, but their results remain heterogeneous.

There are very few studies on the biomechanical anatomy of ejaculation. Ejaculation is a complex phenomenon involving different structures and in particular the Veru Montanum. This is the key element in the emission of ejaculate within the prostatic urethra. In addition, there is a structure located in the resection zone of the prostate adenoma. It has therefore been suggested that its resection was a primary source of ED.

A single observational study carried out in by Gil Vernet et al in 1994 evaluated on a single healthy 18-year-old volunteer the ejaculatory mechanism of expulsion using an endorectal probe recording the movements of the prostate, the bladder neck and of the proximal urethra during ejaculation.

A contemporary study of the biomechanics of the ejaculatory expulsion phase could confirm and improve understanding of the involvement of anatomical structures. The results of our study aim to adapt surgical techniques aimed at limiting the risk of postoperative ED.

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Key information

Conditions

Ejaculatory Dysfunction Genital Diseases Genital Diseases, Male Male Urogenital Diseases Sexual Dysfunction, Physiological Urogenital Diseases

Age range

18 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Clinique Pasteur

Toulouse, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Affiliated subject or beneficiary of a social security scheme
  • Subject agreeing to participate and having signed the free, informed consent.

Exclusion criteria

  • Subject with ejaculatory dysfunction
  • Subject with urinary dysfunction
  • History of urinary or penile surgery
  • Subject with untreated urinary tract infection
  • History of chronic prostatitis
  • Pathology making it impossible to introduce the endorectal probe or the ureteroscope
  • History of colorectal inflammatory disease
  • Recent intake (within 30 days) of drugs known to interfere with ejaculation
  • History of intolerance or allergy to any of the drugs used in the study
  • Subject participating in another clinical study
  • Adults under guardianship, curatorship or other legal protection; deprived of liberty by judicial or administrative decision; Hospitalized without consent.

Treatment and study plan

transrectal ultrasound

Other

Examinations for observation of the pre, per and post-ejaculatory phases

Urethroscopy

Other

Examinations for observation of the pre, per and post-ejaculatory phases

Primary outcomes

  1. Peri-urethral muscle contraction

    Time frame: At Day 0

    Qualitative description of peri-urethral muscle contraction according to ultrasound videos analysis

  2. Urethra, bladder neck and prostate movements

    Time frame: At Day 0

    Qualitative description of movements of the urethra, bladder neck and prostate according to ultrasound videos analysis

  3. Sperm flow within the prostatic urethra

    Time frame: At Day 0

    Qualitative description of sperm flow within the prostatic urethra according to ultrasound videos analysis

  4. Spermatic fluid via the ejaculatory ducts

    Time frame: At Day 6

    Qualitative description of the expulsion and flow of spermatic fluid via the ejaculatory ducts according to urethroscopy videos analysis

  5. Veru montanum mobility and urethral contraction.

    Time frame: At Day 6

    Qualitative description of veru montanum mobility and urethral contraction according to urethroscopy videos analysis

Sponsors and collaborators

Lead sponsor

Clinique Pasteur

Other

Registry information

Official study title

Study of the Biomechanical Anatomy of Ejaculation

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Dec 14, 2022
Registry last updated
Mar 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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