Exploration of Cerebral Pathophysiology During and After CABG Using CPB

Purpose:

The purpose of this study is to examine cerebral oxidative and inflammatory stress and cerebral hemodynamics during and after coronary artery bypass grafting and correlate with postoperative cognitive function.

Completed

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Key information

Conditions

Ischemic Heart Disease Cardiovascular Diseases Cognition Disorders Cognitive Dysfunction Heart Diseases Mental Disorders Myocardial Ischemia Neurocognitive Disorders Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Cognitive Complications Postoperative Complications Vascular Diseases

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

About this study

Postoperative cognitive decline is a well-known and well-described complication following coronary artery bypass grafting. Severity ranges from postoperative delirium to stroke, but the majority of patients with postoperative cognitive decline following coronary artery bypass grafting have decline in recent and remote memory in particular.

The reason for the cognitive decline is still not fully understood though many reasons have been proposed.

Inflammation and oxidative stress may contribute to the postoperative cognitive dysfunction which may also be in combination with a reduced cerebral autoregulation.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with ischemic heart disease admitted for coronary artery bypass grafting with the use of cardiopulmonary bypass

Exclusion criteria

Cerebrovascular disease

Treatment and study plan

Primary outcomes

Cerebral autoregulation

Time frame: 6 hours post operation

Flow measurement of middle cerebral artery and measurement of middel arterial pressure

Secondary outcomes

Postoperative cognitive function

Time frame: One day prior to operation and three days after operation

Sponsors and collaborators

Lead sponsor

Rigshospitalet, Denmark

Other

Registry information

Official study title

Cerebral Oxidative and Inflammatory Stress and Cerebral Hemodynamics During and After Coronary Artery Bypass Grafting With Use of Cardiopulmonary Bypass

Important dates

Study start: 2011
Primary completion: 2012
Study completion: 2012
First posted: Oct 21, 2016
Registry last updated: Oct 21, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed