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OpenTrials
Active, Not Recruiting

NCT Number: NCT05582434

Experience With Topical Acne Treatment

Acne is a chronic condition that typically requires the use of multiple medications.1 Medication adherence is especially challenging for patients with chronic diseases and often decreases over time, especially for those using topical medications.1 Nonadherence can result in multiple negative effects including treatment failure, increased healthcare costs, and decreased quality of life. Primary nonadherence refers to problems acquiring and starting treatment. Challenges to this form of nonadherence include a lack of knowledge, misunderstanding of usage, poor communication with provider, increased cost, and fear of side effects.2 Secondary nonadherence refers to when the patient does not use the medication as prescribed. Hurdles to secondary nonadherence include delayed results, increased complexity of treatment plan, adverse effects, busy lifestyle, and inconvenience.2

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Acne Acne Vulgaris Acneiform Eruptions Sebaceous Gland Diseases Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients ≥18 years of age
  • Patients with a current diagnosis of acne
  • Patients who live in the US,
  • Patients have sufficient command of the English language

Exclusion criteria

  • Patients less than the age of 18
  • Patients without a current diagnosis of acne
  • Patients who do not live in the US
  • Patients without a sufficient command of the English language

Treatment and study plan

clindamycin phosphate 1.2%/adapalene 0.15%/BPO 3.1% gel

Drug

Single topical treatment to be applied daily to area affected once daily.

Other names: Cabtreo®

adapalene 0.3%/BPO 2.5% gel and compounded clindamycin phosphate 1.2% gel

Drug

Two topical treatments to be applied to area affected once daily.

Other names: Epiduo® Forte and Clindamycin

Compounded BPO 2.5% gel, adapalene 0.1% gel, and compounded clindamycin phosphate 1.2% gel

Drug

Three topical treatments to be applied to area affected once daily.

Other names: Differin®, Epsolay, Clindamycin

Primary outcomes

  1. Medication Adherence

    Time frame: End of study visit - day 56

    Medication adherence measured by recording the weight of medication (in milligrams) in the bottle with electronic monitor attached

  2. Medication Adherence

    Time frame: End of study visit - day 56

    Medication adherence measured by the data from the electronic monitors by frequency of use recorded by number of times opened

Secondary outcomes

  1. Gender specific adherence (female subjects)

    Time frame: End of study visit - day 56

    Difference in medication adherence between the male and female subjects. The outcome will compare the two categories in the primary outcome

  2. Gender specific adherence (male subjects)

    Time frame: End of study visit - day 56

    Difference in medication adherence between the male and female subjects. The outcome will compare the two categories in the primary outcome

Sponsors and collaborators

Lead sponsor

Wake Forest University Health Sciences

Other

Collaborators

  • Bausch Health Americas, Inc.

Registry information

Official study title

Factors Affecting Medication Adherence to Topical Acne Medications: a Single-center, Prospective Study Evaluating the Adherence and Patient Satisfaction to Single and Multiple Topical Acne Medications

Important dates

Study start
2024
Primary completion
2025
Study completion
2026
First posted
Oct 17, 2022
Registry last updated
Dec 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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