Exparel PK and Breast Milk Excretion

Inclusion criteria

• Pregnant women >18 year old, scheduled for elective Cesarean delivery and who desire to have a TAP block performed after delivery.
• American Society of Anesthesiologists physical status I, II, and III

Exclusion criteria

• Patient refusal or inability to cooperate.
• Allergy, hypersensitivity, intolerance, or contraindication to liposomal bupivacaine.
• Severely impaired renal or hepatic function (eg, serum creatinine level >2 mg/dL [176.8 µmol/L], blood urea nitrogen level >50 mg/dL [17.9 mmol/L], serum aspartate aminotransferase [AST] level >3 times the upper limit of normal [ULN], or serum alanine aminotransferase [ALT] level >3 times the ULN).
• Participants at an increased risk for bleeding or with any coagulation disorder (defined as platelet count less than 80, 000 × 103/mm3 or international normalized ratio greater than 1.5) (all contraindications to TAP block).
• Clinically significant medical disease in either the mother or baby that, in the opinion of the investigator, would make participation in a clinical study inappropriate. This includes any psychiatric or other disease in the mother that would constitute a contraindication to participation in the study or cause the mother to be unable to comply with the study requirements.
• Patient membership in a vulnerable population such as a prisoner, mentally unable to provide direct consent etc.
• Participant has contraindication to breastfeeding or not planning to breastfeed the first 2-3 days after delivery.