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Completed

NCT Number: NCT03731065

Exogenous Oxidation of Fructose-glucose Mixtures During Running

The aim of this study is to characterise exogenous carbohydrate oxidation rates during exercise, when ingesting glucose (polymers) only, compared to glucose-fructose mixtures, and glucose-fructose mixtures ingested in hydrogel form.

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Key information

Conditions

Exercise Behavior Motor Activity

Age range

18 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Department for Health, University of Bath

Bath, BA2 7AY, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Maximal oxygen consumption > 50 ml.kg-1.min-1
  • > 1 year training in endurance running or triathlon
  • No current injury or injury within the last three months
  • No history of cardiac or metabolic disease such as coronary heart disease or diabetes
  • No current or history of gastrointestinal issues
  • Successful completion of the physical activity readiness questionnaire (PAR-Q)

Exclusion criteria

  • Female
  • Untrained in endurance running
  • Current injury or injury within the past three months
  • History of cardiac or metabolic disease such as coronary heart disease or diabetes
  • History of or current gastrointestinal issues such as irritable bowel syndrome
  • Unable to replicate diet and training for 3 and 5 days respectively prior to each experimental visit.

Treatment and study plan

Fructose-maltodextrin

Dietary Supplement

Fructose plus maltodextrin in a ratio of 1:1.4, diluted in water to produce a 16% carbohydrate solution.

Fructose-maltodextrin hydrogel

Dietary Supplement

Fructose plus maltodextrin in a ratio of 1:1.4, encapsulated in an alginate-pectin hydrogel diluted in water to produce a 16% carbohydrate solution.

Glucose-maltodextrin

Dietary Supplement

Glucose plus maltodextrin in a ratio of 1:1.4, diluted in water to produce a 16% carbohydrate solution.

Primary outcomes

  1. Peak exogenous carbohydrate oxidation rate

    Time frame: 120 minutes

    Peak exogenous carbohydrate oxidation rate during 120 min of treadmill running. Measured using isotope ratio mass spectrometry and reported in grams per minute

Secondary outcomes

  1. Total carbohydrate oxidation

    Time frame: 120 minutes

    Total carbohydrate oxidation during 120 min of treadmill running. Measured using indirect calorimetry and reported in grams.

  2. Ratings of gastrointestinal discomfort

    Time frame: 120 minutes

    Subjective ratings of gastrointestinal discomfort during 120 min of treadmill running. Measured using a 9-item questionnaire on a scale of 1 to 7, where 1 = No discomfort at all and 7 = very severe discomfort.

    Items: Stomach; Heartburn; Acid reflux; Nausea; Rumbling; Bloated; Burping; Passing gas; Bowel movement.

  3. Total fat oxidation

    Time frame: 120 minutes

    Total fat oxidation during 120 min of treadmill running. Measured using indirect calorimetry and reported in grams.

  4. Plasma insulin concentrations

    Time frame: 120 minutes

    Plasma insulin concentrations during 120 min of treadmill running. Measured using enzyme-linked immunosorbent assay and reported in pmol/L.

  5. Plasma glucose concentrations

    Time frame: 120 minutes

    Plasma lactate concentrations during 120 min of treadmill running. Measured using colourimetric assay and reported in mmol/L.

  6. Plasma lactate concentrations

    Time frame: 120 minutes

    Plasma lactate concentrations during 120 min of treadmill running. Measured using colourimetric assay and reported in mmol/L.

  7. Plasma non-esterified fatty acid concentrations

    Time frame: 120 minutes

    Plasma insulin concentrations during 120 min of treadmill running. Measured using colourimetric assay and reported in umol/L.

  8. Ratings of perceived exertion

    Time frame: 120 minutes

    Subjective ratings of perceived exertion using the Borg scale (1982) during 120 min of treadmill running. Measured on a scale of 6 to 20, where 6 = no exertion at all, and 20 = maximal exertion.

  9. Heart rate

    Time frame: 120 minutes

    Heart rate during treadmill running measured by telemetry and reported in beats per minute.

  10. Rate of oxygen consumption

    Time frame: 120 minutes

    Rate of oxygen consumption during 120 min of treadmill running. Measured using indirect calorimetry and reported in litres per minute.

  11. Rate of carbon dioxide production

    Time frame: 120 minutes

    Rate of carbon dioxide production during 120 min of treadmill running. Measured using indirect calorimetry and reported in litres per minute.

Sponsors and collaborators

Lead sponsor

University of Bath

Other

Collaborators

  • University of Birmingham

Registry information

Official study title

Examining Exogenous Carbohydrate Oxidation From Glucose, Multiple Transportable Carbohydrates and Hydrogel Carbohydrate Drinks During Endurance Running

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Nov 6, 2018
Registry last updated
Dec 10, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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